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题目:: Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome.
作者:: Michaux(L),Wlodarska(I),Theate(I),Stul(M),Scheiff(J-M),Deneys(V),Ferrant(A),Hagemeijer(A)
状态:: 发布时间2004-09-27 , 更新时间 2006-11-15
期刊:: Ann Hematol
摘要:: A patient with mantle cell lymphoma (MCL) of the pleomorphic blastoid subtype is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient survived only 2 months. Cytogenetically, a t(11;19;14)(q13;q13;q32) was found. Fluorescent in situ hybridization (FISH) and molecular analyses demonstrated involvement of the BCL1/CCND1 locus in a three-way translocation. In addition, subclonal abnormalities of the region 8q24 manifested either as a t(8;22)(q24;q11)/CMYC rearrangement or trisomy 8 were identified. The pathogenetic impact of this very uncommon association of BCL1/CCND1 and CMYC rearrangements in MCL is discussed and the literature is reviewed.
语言:: eng
DOI:: 10.1007/s00277-004-0879-2

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