Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.

Clinical and diagnostic laboratory immunology ·Vol. 11 ·No. 3 ·2004-05-00 ·Pages 625-6

Ben-Ali M, Barbouche MR, Bousnina S, Chabbou A, Dellagi K

Abstract

Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.

MeSH Terms

Adult Aged Base Sequence DNA/chemistry,genetics,isolation & purification DNA Mutational Analysis Gene Frequency/genetics Genetic Predisposition to Disease/genetics Genotype Heterozygote Humans Membrane Glycoproteins/genetics Middle Aged Polymerase Chain Reaction Polymorphism, Single Nucleotide/genetics Receptors, Cell Surface/genetics Toll-Like Receptor 2 Toll-Like Receptors Tuberculosis, Pulmonary/diagnosis,genetics Tunisia

Chemicals

Membrane Glycoproteins Receptors, Cell Surface TLR2 protein, human Toll-Like Receptor 2 Toll-Like Receptors DNA

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Ben-Ali Meriem

Laboratoire d'Immunologie, de Vaccinologie et de Génétique Moléculaire, Institut Pasteur de Tunis, 13, Place Pasteur, 1002 Tunis, Tunisia.

Barbouche Mohamed-Ridha

Bousnina Soufia

Chabbou Abdellatif

Dellagi Koussay

References (13)

13 references, click to expand

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Article Info

Journal

Clinical and diagnostic laboratory immunology

Abbr.

Clin Diagn Lab Immunol

ISSN

1071-412X

DOI

10.1128/CDLI.11.3.625-626.2004

Published

2004-05-00

Pages

625-6

Language

English

Region

United States

NLM ID

9421292

PMCID

PMC404573

Subset

External Links

PubMed source DOI: 10.1128/CDLI.11.3.625-626.2004 PMC Full Text

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Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.

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