Chronic excretion of a norovirus in a child with cartilage hair hypoplasia (CHH).

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology ·Vol. 30 ·No. 2 ·2004-06-00 ·Pages 196-204

Gallimore CI, Lewis D, Taylor C, Cant A, Gennery A, Gray JJ

Abstract

We have demonstrated the long-term excretion of a stable recombinant norovirus in a patient with cartilage hair hypoplasia (CHH), with a T cell immunodeficiency, following bone marrow transplantation (BMT). The patient excreted an ARG320/1999/US-like recombinant norovirus (rGII-3) for 156 days during a period of immune reconstitution. The child was symptomatic during the period of virus shedding. It is not known if the child acquired the recombinant strain or if recombination occurred in vivo.

MeSH Terms

Abnormalities, Multiple/virology Amino Acid Sequence Base Sequence Cartilage/abnormalities Dwarfism Hair/abnormalities Humans Immunologic Deficiency Syndromes/virology Infant Molecular Sequence Data Norovirus/classification,genetics,isolation & purification Osteochondrodysplasias Phylogeny Recombination, Genetic Sequence Alignment Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Gallimore Chris I

Central Public Health Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency, Colindale, London, UK. christopher.gallimore@hpa.org.uk

Lewis David

Taylor Clive

Cant Andrew

Gennery Andrew

Gray Jim J

Article Info

Journal

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

Abbr.

J Clin Virol

ISSN

1386-6532

DOI

10.1016/j.jcv.2003.10.007

christopher.gallimore@hpa.org.uk

Published

2004-06-00

Pages

196-204

Language

English

Region

Netherlands

NLM ID

9815671

Subset

External Links

PubMed source DOI: 10.1016/j.jcv.2003.10.007 View journal details

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Chronic excretion of a norovirus in a child with cartilage hair hypoplasia (CHH).

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