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PMID: 15114340 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Structure and mechanism of the RNA polymerase II transcription machinery.

Nature structural & molecular biology ·Vol. 11 ·No. 5 ·2004-05-00 ·Pages 394-403

Hahn S

Abstract

Advances in structure determination of the bacterial and eukaryotic transcription machinery have led to a marked increase in the understanding of the mechanism of transcription. Models for the specific assembly of the RNA polymerase II transcription machinery at a promoter, conformational changes that occur during initiation of transcription, and the mechanism of initiation are discussed in light of recent developments.

MeSH Terms
Models, Molecular Promoter Regions, Genetic Protein Conformation RNA Polymerase II/chemistry,metabolism Structure-Activity Relationship
Chemicals
RNA Polymerase II
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hahn Steven
Fred Hutchinson Cancer Research Center and Howard Hughes Medical Institute, 1100 Fairview Ave N., A1-162, Seattle, Washington 98109, USA. shahn@fhcrc.org
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Article Info
Journal
Nature structural & molecular biology
Abbr.
Nat Struct Mol Biol
ISSN
1545-9993
DOI
10.1038/nsmb763
Email
shahn@fhcrc.org
Published
2004-05-00
Pages
394-403
Language
English
Region
United States
NLM ID
101186374
PMCID
PMC1189732
Subset
IM
Grants
NIGMS NIH HHS · R01 GM053451 · United States
External Links
PubMed source DOI: 10.1038/nsmb763 PMC Full Text View journal details
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