Dynamic properties of salmon calcitonin bound to sodium dodecyl sulfate micelles: a restrained molecular dynamics study from NMR data.

Journal of biomolecular NMR ·Vol. 2 ·No. 4 ·1992-07-00 ·Pages 335-48

Castiglione Morelli MA, Pastore A, Motta A

Abstract

We have investigated the conformational behaviour of salmon calcitonin bound to sodium dodecyl sulfate micelles by means of restrained molecular dynamics simulations with both 'static' and time-averaged NMR distance restraints. A more realistic picture of the inherent flexibility of the hormone is obtained when using time averaging. With this approach, long-range NOEs are interpreted better by considering a dynamical exchange among different conformations.

MeSH Terms

Amino Acid Sequence Animals Calcitonin/chemistry,metabolism Magnetic Resonance Spectroscopy Micelles Molecular Sequence Data Salmon Sodium Dodecyl Sulfate/metabolism

Chemicals

Micelles Sodium Dodecyl Sulfate Calcitonin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Castiglione Morelli M A

European Molecular Biology Laboratory, Heidelberg, Germany.

Pastore A

Motta A

References (18)

18 references, click to expand

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Article Info

Journal

Journal of biomolecular NMR

Abbr.

J Biomol NMR

ISSN

0925-2738

DOI

10.1007/BF01874812

Published

1992-07-00

Pages

335-48

Language

English

Region

Netherlands

NLM ID

9110829

Subset

External Links

PubMed source DOI: 10.1007/BF01874812 View journal details

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Dynamic properties of salmon calcitonin bound to sodium dodecyl sulfate micelles: a restrained molecular dynamics study from NMR data.

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