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题目:: The role of tumour suppressor genes in familial cancer.
作者:: Malkin(D),Friend(S H)
状态:: 发布时间1992-09-29 , 更新时间 2006-11-15
期刊:: Semin Cancer Biol
摘要:: Many forms of cancer have a higher incidence in relatives of patients than in the general population, and some show Mendelian inheritance. Although individuals genetically predisposed to cancer represent a minority of all cancer patients, the genetic basis for their disease has profound significance. These familial cases provide strong evidence that germline alterations can contribute to cancer. They also provide an ideal opportunity to identify and isolate the genes mutated in common cancers. Products of the tumour suppressor genes have been implicated in several hereditary forms of cancer. The distinct functions of these proteins and their roles in familial cancer will be discussed.
语言:: eng
DOI:

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