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PMID: 15097993 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Towing of sensory axons by their migrating target cells in vivo.

Nature neuroscience ·Vol. 7 ·No. 5 ·2004-05-00 ·Pages 491-2

Gilmour D, Knaut H, Maischein HM, Nüsslein-Volhard C

Abstract

Many pathfinding axons must locate target fields that are themselves positioned by active migration. A hypothetical method for ensuring that these migrations are coordinated is towing, whereby the extension of axons is entirely dependent on the migration of their target cells. Here we combine genetics and time-lapse imaging in the zebrafish to show that towing by migrating cells is a bona fide mechanism for guiding pathfinding axons in vivo.

MeSH Terms

Animals Animals, Genetically Modified Axons/physiology Cell Communication/genetics Cell Movement/physiology Chemokine CXCL12 Chemokines, CXC/metabolism Diagnostic Imaging/methods Embryo, Nonmammalian Green Fluorescent Proteins Growth Cones In Situ Hybridization/methods Luminescent Proteins Neurons, Afferent/cytology,physiology,transplantation Receptors, CXCR4/genetics Signal Transduction Time Factors Transplantation/methods Zebrafish Zebrafish Proteins/genetics

Chemicals

CXCR4b protein, zebrafish Chemokine CXCL12 Chemokines, CXC Luminescent Proteins Receptors, CXCR4 Zebrafish Proteins Green Fluorescent Proteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Gilmour Darren

Max Planck Institut für Entwicklungsbiologie, Abteilung Genetik, Spemannstrasse 35, 72076 Tuebingen, Germany. darren.gilmour@tuebingen.mpg.de

Knaut Holger

Maischein Hans-Martin

Nüsslein-Volhard Christiane

Article Info

Journal

Nature neuroscience

Abbr.

Nat Neurosci

ISSN

1097-6256

DOI

10.1038/nn1235

darren.gilmour@tuebingen.mpg.de

Published

2004-05-00

Epub

2004-00-18

Pages

491-2

Language

English

Region

United States

NLM ID

9809671

Subset

External Links

PubMed source DOI: 10.1038/nn1235 View journal details

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Towing of sensory axons by their migrating target cells in vivo.

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