The biosynthesis of the mitochondrial ADP, ATP translocator.

European journal of biochemistry ·Vol. 88 ·No. 2 ·1978-08-01 ·Pages 373-8

Hackenberg H, Riccio P, Klingenberg M

Abstract

The biosynthesis of the ADP,ATP carrier was studied in mitochondria of Neurospora crassa. The carrier was isolated as the carboxyatractylate-protein complex and characterized in dodecylsulphate/polyacrylamide gel electrophoresis to have a Mr = 33 000. Applying the inhibitors chloramphenicol for the intramitochondrial translation and cycloheximide for extramitochondrial translation, the site of synthesis of this polypeptide was found to be extramitochondrially located.

MeSH Terms

Adenosine Diphosphate/metabolism Adenosine Triphosphate/metabolism Biological Transport Carrier Proteins/isolation & purification Chloramphenicol/pharmacology Cycloheximide/pharmacology Mitochondria/metabolism Mitochondrial ADP, ATP Translocases/biosynthesis Molecular Weight Neurospora/metabolism Neurospora crassa/metabolism Nucleotidyltransferases/biosynthesis Protein Biosynthesis/drug effects

Chemicals

Carrier Proteins Adenosine Diphosphate Chloramphenicol Adenosine Triphosphate Mitochondrial ADP, ATP Translocases Cycloheximide Nucleotidyltransferases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Hackenberg H

Riccio P

Klingenberg M

Article Info

Journal

European journal of biochemistry

Abbr.

Eur J Biochem

ISSN

0014-2956

DOI

10.1111/j.1432-1033.1978.tb12458.x

Published

1978-08-01

Pages

373-8

Language

English

Region

England

NLM ID

0107600

Subset

External Links

PubMed source DOI: 10.1111/j.1432-1033.1978.tb12458.x

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