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PMID: 15094132 Published · ppublish English Journal Article Review

Genetic factors of age-related macular degeneration.

Progress in retinal and eye research ·Vol. 23 ·No. 2 ·2004-03-00 ·Pages 229-49

Tuo J, Bojanowski CM, Chan CC

Abstract

Age-related macular degeneration (AMD) is a leading cause of blindness in the United States and developed countries. Although the etiology and pathogenesis of AMD remain unknown, a complex interaction of genetic and environmental factors is thought to exist. The incidence and progression of all of the features of AMD are known to increase significantly with age. The tendency for familial aggregation and the findings of gene variation association studies implicate a significant genetic component in the development of AMD. This review summarizes in detail the AMD-related genes identified by studies on genetically engineered and spontaneously gene-mutated (naturally mutated) animals, AMD chromosomal loci identified by linkage studies, AMD-related genes identified through studies of monogenic degenerative retinal diseases, and AMD-related gene variation identified by association studies.

MeSH Terms
Genetic Predisposition to Disease/genetics Humans Macular Degeneration/genetics Risk Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tuo Jingsheng
Laboratory of Immunology, Immunopathology Section, National Eye Institute, National Institutes of Health, Bldg. 10, Rm. 10N103, 10 Center Drive, Bethesda, MD 20892-1857, USA.
Bojanowski Christine M
Chan Chi-Chao
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Article Info
Journal
Progress in retinal and eye research
Abbr.
Prog Retin Eye Res
ISSN
1350-9462
DOI
10.1016/j.preteyeres.2004.02.001
Published
2004-03-00
Pages
229-49
Language
English
Region
England
NLM ID
9431859
PMCID
PMC1950336
Subset
IM
Grants
Intramural NIH HHS · Z01 EY000418-04 · United States
External Links
PubMed source DOI: 10.1016/j.preteyeres.2004.02.001 PMC Full Text View journal details
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