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PMID: 1509265 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Transactivation by AP-1 is a molecular target of T cell clonal anergy.

Science (New York, N.Y.) ·Vol. 257 ·No. 5073 ·1992-08-21 ·Pages 1134-8

Kang SM, Beverly B, Tran AC, Brorson K, Schwartz RH, Lenardo MJ

Abstract

Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element.

MeSH Terms

Animals Antigen-Presenting Cells/immunology Antigens/immunology Base Sequence Binding Sites Blotting, Northern Cell Line Concanavalin A/pharmacology Gene Expression Regulation Immune Tolerance Interleukin-2/genetics,pharmacology Mice Molecular Sequence Data Mutation Promoter Regions, Genetic/genetics Proto-Oncogene Proteins c-jun/physiology RNA, Messenger/metabolism Receptors, Antigen, T-Cell/immunology T-Lymphocytes/immunology Transcription, Genetic Transfection

Chemicals

Antigens Interleukin-2 Proto-Oncogene Proteins c-jun RNA, Messenger Receptors, Antigen, T-Cell Concanavalin A

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Kang S M

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Beverly B

Tran A C

Brorson K

Schwartz R H

Lenardo M J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.257.5073.1134

Published

1992-08-21

Pages

1134-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.257.5073.1134 View journal details

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Transactivation by AP-1 is a molecular target of T cell clonal anergy.

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