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PMID: 15073366 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

How viruses enter animal cells.

Science (New York, N.Y.) ·Vol. 304 ·No. 5668 ·2004-04-09 ·Pages 237-42

Smith AE, Helenius A

Abstract

Viruses replicate within living cells and use the cellular machinery for the synthesis of their genome and other components. To gain access, they have evolved a variety of elegant mechanisms to deliver their genes and accessory proteins into the host cell. Many animal viruses take advantage of endocytic pathways and rely on the cell to guide them through a complex entry and uncoating program. In the dialogue between the cell and the intruder, the cell provides critical cues that allow the virus to undergo molecular transformations that lead to successful internalization, intra-cellular transport, and uncoating.

MeSH Terms
Active Transport, Cell Nucleus Animals Carbohydrate Metabolism Cell Nucleus/virology Cell Physiological Phenomena Cells/virology Cytosol/virology Endocytosis Genome, Viral Membrane Fusion Membrane Microdomains/physiology Receptors, Virus/metabolism Signal Transduction Viral Proteins/metabolism Virion/physiology Virus Physiological Phenomena
Chemicals
Receptors, Virus Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Smith Alicia E
Institute of Biochemistry, Swiss Federal Institute of Technology-Zurich, CH-8093 Zurich, Switzerland.
Helenius Ari
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2004-04-09
Pages
237-42
Language
English
Region
United States
NLM ID
0404511
Subset
IM
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