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PMID: 15069709 Published · ppublish English Journal Article

C-reactive protein, procalcitonin, interleukin-6, vascular endothelial growth factor and oxidative metabolites in diagnosis of infection and staging in patients with gastric cancer.

World journal of gastroenterology ·Vol. 10 ·No. 8 ·2004-04-15 ·Pages 1115-20

Ilhan N, Ilhan N, Ilhan Y, Akbulut H, Kucuksu M

Abstract

The current study was to determine the serum/plasma levels of VEGF, IL-6, malondialdehyde (MDA), nitric oxide (NO), PCT and CRP in gastric carcinoma and correlation with the stages of the disease and accompanying infection. We examined the levels of serum VEGF, IL-6, PCT, CRP and plasma MDA, NO in 42 preoperative gastric cancer patients and 23 healthy subjects. There were infection anamneses that had no definite origin in 19 cancer patients. The VEGF levels (mean+/-SD; pg/mL) were 478.05+/-178.29 and 473.85+/-131.24 in gastric cancer patients with and without infection, respectively, and these values were not significantly different (P>0.05). The levels of VEGF, CRP, PCT, IL-6, MDA and NO in cancer patients were significantly higher than those in healthy controls and the levels of CRP, PCT, IL-6, MDA and NO were statistically increased in infection group when compared with non-infection group (P<0.001). Although serum VEGF concentrations were increased in gastric cancer, this increase might not be related to infection. CRP, PCT, IL-6, MDA and NO have obvious drawbacks in the diagnosis of infections in cancer patients. These markers may not help to identify infections in the primary evaluation of cancer patients and hence to avoid unnecessary antibiotic treatments as well as hospitalization. According to the results of this study, IL-6, MDA, NO and especially VEGF can be used as useful parameters to diagnose and grade gastric cancer.

MeSH Terms
Abdominal Pain/blood,diagnosis Aged Biomarkers Biomarkers, Tumor/blood C-Reactive Protein/metabolism Calcitonin/blood Calcitonin Gene-Related Peptide Female Helicobacter Infections/blood,diagnosis Humans Interleukin-6/blood Male Malnutrition/blood,diagnosis Malondialdehyde/blood Middle Aged Neoplasm Staging Nitric Oxide/blood Oxidative Stress Protein Precursors/blood Stomach Neoplasms/blood,pathology Vascular Endothelial Growth Factor A/blood Vomiting/blood,diagnosis Weight Loss
Chemicals
Biomarkers Biomarkers, Tumor CALCA protein, human Interleukin-6 Protein Precursors Vascular Endothelial Growth Factor A Nitric Oxide Malondialdehyde Calcitonin C-Reactive Protein Calcitonin Gene-Related Peptide
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ilhan Nevin
Flrat Universitesi, Flrat Tlp Merkezi, Biyokimya ve Klinik Biyokimya AD, 23119, Elazig, Turkey. drnilhan@yahoo.com
Ilhan Necip
Ilhan Yavuz
Akbulut Handan
Kucuksu Mehmet
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Article Info
Journal
World journal of gastroenterology
Abbr.
World J Gastroenterol
ISSN
1007-9327
DOI
10.3748/wjg.v10.i8.1115
Email
drnilhan@yahoo.com
Published
2004-04-15
Pages
1115-20
Language
English
Region
United States
NLM ID
100883448
PMCID
PMC4656344
Subset
IM
External Links
PubMed source DOI: 10.3748/wjg.v10.i8.1115 PMC Full Text View journal details
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