Abstract
Osteoporosis, characterized by low bone mass and structural deterioration of bone tissue with an increased susceptibility to fractures, is a major public health threat to the elderly. Bone mass homeostasis in adults is maintained locally by the balance between osteoblastic bone formation and osteoclastic bone resorption. Haploinsufficiency of PPARgamma, a key transcription factor implicated previously in adipogenesis, lipid metabolism, and glucose homeostasis, has now been shown to promote osteogenesis through enhanced osteoblast formation. These findings support a reciprocal relationship between the development of bone and fat, and may prompt further exploration of the PPAR pathway as a potential target for intervention in osteoporosis.
MeSH Terms
Adipose Tissue/metabolism
Animals
Bone and Bones/metabolism
Osteoblasts/metabolism
Osteoclasts/metabolism
Osteoporosis/metabolism
Receptors, Cytoplasmic and Nuclear/metabolism
Transcription Factors/metabolism
Chemicals
Receptors, Cytoplasmic and Nuclear
Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pei Liming
Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California 90095-1662, USA.
Tontonoz Peter
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