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PMID: 15052411 Published · ppublish English Journal Article Review

The ABC transporter structure and mechanism: perspectives on recent research.

Cellular and molecular life sciences : CMLS ·Vol. 61 ·No. 6 ·2004-03-00 ·Pages 682-99

Jones PM, George AM

Abstract

ATP-binding cassette (ABC) transporters are multidomain integral membrane proteins that utilise the energy of ATP hydrolysis to translocate solutes across cellular membranes in all phyla. ABC transporters form one of the largest of all protein families and are central to many important biomedical phenomena, including resistance of cancers and pathogenic microbes to drugs. Elucidation of the structure and mechanism of ABC transporters is essential to the rational design of agents to control their function. While a wealth of high-resolution structures of ABC proteins have been produced in recent years, many fundamental questions regarding the protein's mechanism remain unanswered. In this review, we examine the recent structural data concerning ABC transporters and related proteins in the light of other experimental and theoretical data, and discuss these data in relation to current ideas concerning the transporters' molecular mechanism.

MeSH Terms
ATP-Binding Cassette Transporters/chemistry,physiology Adenosine Triphosphate/metabolism Amino Acid Sequence Catalysis Catalytic Domain Cell Membrane/metabolism Hydrolysis Models, Molecular Molecular Sequence Data Nucleotides/metabolism Protein Binding Protein Conformation Sequence Homology, Amino Acid
Chemicals
ATP-Binding Cassette Transporters Nucleotides Adenosine Triphosphate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jones P M
Department of Cell and Molecular Biology, University of Technology Sydney, Broadway, NSW, Australia.
George A M
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Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-682X
DOI
10.1007/s00018-003-3336-9
Published
2004-03-00
Pages
682-99
Language
English
Region
Switzerland
NLM ID
9705402
Subset
IM
External Links
PubMed source DOI: 10.1007/s00018-003-3336-9 View journal details
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