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题目:: Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer.
作者:: Downing(Sean R),Hennessy(Kristen T),Abe(Miyako),Manola(Judith),George(Daniel J),Kantoff(Philip W)
状态:: 发布时间2004-03-25 , 更新时间 2007-11-14
期刊:: Clin Prostate Cancer
摘要:: Several genetic loci are suspected to be involved in hereditary prostate cancer, including the hereditary prostate cancer 1 (HPC1) locus at chromosome 1q24-25. The ribonuclease L (RNase L) gene has been reported as the putative hereditary prostate cancer gene located at HPC1. If this is the case, mutations of RNase L should be found at a greater frequency in familial cancers than in sporadic prostate cancers. Examination of familial and sporadic cases of prostate cancer by polymerase chain reaction and DNA sequencing resulted in a mutational frequency rate that was not statistically different between the 2 forms of the disease. These results suggest that the mutations examined within this study are rare and may contribute to very few familial prostate cancers.
语言:: eng
DOI:

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