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PMID: 1503910 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Separable growth and migration factors for large-cell lymphoma cells secreted by microvascular endothelial cells derived from target organs for metastasis.

British journal of cancer ·Vol. 66 ·No. 2 ·1992-08-00 ·Pages 349-54

Hamada J, Cavanaugh PG, Lotan O, Nicolson GL

Abstract

Metastatic variant sublines of the murine large-cell lymphoma cell line RAW117 were tested for their growth and migration properties in vitro in medium conditioned by soluble factors released from syngeneic mouse liver-, lung-, and brain-derived microvessel endothelial cells. Medium conditioned with hepatic sinusoidal endothelial cells stimulated the growth of highly liver-colonising (RAW117-H10) and highly liver- and lung-colonising (RAW117-L17) sublines at higher rates than the poorly metastatic parental line (RAW117-P) (H10 greater than L17 greater than P). Medium conditioned with lung microvessel endothelial cells selectively stimulated the growth of the lung-colonising RAW117-L17 subline. Medium conditioned with brain microvessel endothelial cells showed no growth selectivity, and equivalently stimulated the growth of various RAW117 cell sublines. Medium conditioned with hepatic sinusoidal endothelial cells preferentially promoted the migration of the liver-colonising H10 and L17 sublines, and medium conditioned with lung endothelial cells differentially stimulated the migration of the lung-colonising L17 subline; whereas medium conditioned with brain endothelial cells only slightly stimulated the migration of L17, but not H10 or P cells. Fractionation of medium conditioned with hepatic sinusoidal endothelial cells by DEAE Sephacel anion exchange chromatography revealed that the growth-stimulating activities were clearly separable from migration-stimulating activities. The growth- and migration-stimulating activities released from organ microvessel endothelial cells may be important in determining the ability of RAW117 cells to selectively form metastatic colonies in particular organs.

MeSH Terms
Animals Cell Communication Cell Division/physiology Cell Line Cell Movement/physiology Chromatography, Ion Exchange Culture Media Endothelium, Vascular/physiology Growth Substances/isolation & purification Lymphoma, Large B-Cell, Diffuse Mice Microcirculation/physiology Neoplasm Metastasis Regional Blood Flow
Chemicals
Culture Media Growth Substances
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hamada J
Department of Tumor Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Cavanaugh P G
Lotan O
Nicolson G L
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1992.269
Published
1992-08-00
Pages
349-54
Language
English
Region
England
NLM ID
0370635
PMCID
PMC1977823
Subset
IM
Grants
NCI NIH HHS · P30-CA 16672 · United States
NCI NIH HHS · R35-CA44352 · United States
External Links
PubMed source DOI: 10.1038/bjc.1992.269 PMC Full Text View journal details
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