Home LiteratureArticle Details
PMID: 15034223 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Ion channels and amino acid transporters support the growth and invasion of primary brain tumors.

Molecular neurobiology ·Vol. 29 ·No. 1 ·2004-02-00 ·Pages 61-71

Sontheimer H

Abstract

The malignant growth of glial support cells causes gliomas, highly invasive, primary brain tumors that are largely resistant to therapy. Individual tumor cells spread by active cell migration, invading diffusely into the normal brain. This process is facilitated by Cl- channels that endow glioma cells with an enhanced ability to quickly adjust their shape and cell volume to fit the narrow and tortuous extracellular brain spaces. Once satellite tumors enlarge, their growth is limited by the spatial constraints imposed by the bony cavity of the skull and spinal column. Glioma cells circumvent this limitation by active destruction of peritumoral neural tissue through the release of glutamate, inducing peritumoral seizures and ultimately excitotoxic neuronal cell death. Hence, primary brain tumors support their unusual biology by taking advantage of ion channels and transporters that are designed to support ion homeostatic functions in normal brain.

MeSH Terms
Amino Acid Transport Systems/metabolism Animals Brain Neoplasms/metabolism,pathology Cell Division Glioma/metabolism,pathology Glutamic Acid/metabolism Humans Ion Channels/metabolism Neoplasm Invasiveness
Chemicals
Amino Acid Transport Systems Ion Channels Glutamic Acid
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Sontheimer Harald
Department of Neurobiology and Civitan International Research Center, the University of Alabama at Birmingham, Birmingham, AL, USA. sontheimer@uab.edu
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Article Info
Journal
Molecular neurobiology
Abbr.
Mol Neurobiol
ISSN
0893-7648
DOI
10.1385/MN:29:1:61
Email
sontheimer@uab.edu
Published
2004-02-00
Pages
61-71
Language
English
Region
United States
NLM ID
8900963
PMCID
PMC2548410
Subset
IM
Grants
NINDS NIH HHS · R01 NS031234-10 · United States
NINDS NIH HHS · R01 NS031234 · United States
NICHD NIH HHS · P01 HD038760-040005 · United States
NICHD NIH HHS · P01 HD038760-030005 · United States
NINDS NIH HHS · R01 NS-36692 · United States
NINDS NIH HHS · R01 NS036692-08 · United States
NINDS NIH HHS · R01 NS036692-05A1 · United States
NCI NIH HHS · P50 CA097247 · United States
NINDS NIH HHS · R01 NS036692-07 · United States
NCI NIH HHS · P50 CA097247-010003 · United States
NICHD NIH HHS · P01 HD038760 · United States
NINDS NIH HHS · R01 NS-31234 · United States
NINDS NIH HHS · R01 NS052634 · United States
NINDS NIH HHS · R01 NS036692 · United States
NICHD NIH HHS · P01 HD038760-050005 · United States
NICHD NIH HHS · P01-HD38760 · United States
NCI NIH HHS · P50-CA97247 · United States
NINDS NIH HHS · R01 NS036692-06 · United States
NINDS NIH HHS · R01 NS031234-11 · United States
External Links
PubMed source DOI: 10.1385/MN:29:1:61 PMC Full Text View journal details
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