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题目:: CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations.
作者:: Arce(Sergio),Luger(Elke),Muehlinghaus(Gwendolin),Cassese(Giuliana),Hauser(Anja),Horst(Alexander),Lehnert(Katja),Odendahl(Marcus),Hönemann(Dirk),Heller(Karl-Dieter),Kleinschmidt(Harald),Berek(Claudia),Dörner(Thomas),Krenn(Veit),Hiepe(Falk),Bargou(Ralf),Radbruch(Andreas),Manz(Rudolf A)
状态:: 发布时间2004-06-03 , 更新时间 2014-11-20
期刊:: J Leukoc Biol
摘要:: Despite the important role immunoglobulin G (IgG)-secreting plasma cells play in memory immune responses, the differentiation and homeostasis of these cells are not completely understood. Here, we studied the differentiation of human IgG-secreting cells ex vivo and in vitro, identifying these cells by the cellular affinity matrix technology. Several subpopulations of IgG-secreting cells were identified among the cells isolated from tonsils and bone marrow, particularly differing in the expression levels of CD9, CD19, and CD38. CD38 low IgG-secreting cells were present exclusively in the tonsils. A major fraction of these cells appeared to be early plasma cell precursors, as upon activation of B cells in vitro, IgG secretion preceded up-regulation of CD38, and on tonsillar sections, IgG-containing, CD38 low cells with a plasmacytoid phenotype were found in follicles, where plasma cell differentiation starts. A unitary phenotype of migratory peripheral blood IgG-secreting cells suggests that all bone marrow plasma cell populations share a common precursor cell. These data are compatible with a multistep model for plasma cell differentiation and imply that a common CD38 low IgG-secreting precursor gives rise to a diverse plasma cell compartment.
语言:: eng
DOI:

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