c-maf in multiple myeloma: an oncogene enhancing tumor-stroma interactions.

Cancer cell ·Vol. 5 ·No. 2 ·2004-02-00 ·Pages 109-10

Kienast J, Berdel WE

Abstract

Gene expression profiling studies reported by Hurt et al. in this issue of Cancer Cell reveal an unexpectedly frequent overexpression of c-maf in multiple myeloma and identify molecular targets of c-maf transactivation. The results define c-maf as a prototype of a class of oncogenes that not only stimulate cell cycle progression, but also promote pathological interactions between tumor and stroma cells.

MeSH Terms

Cadherins/metabolism Cell Communication/physiology Cell Cycle/physiology Cyclin D2 Cyclins/metabolism DNA-Binding Proteins/metabolism Gene Expression Profiling Humans Integrin beta Chains/metabolism Multiple Myeloma/metabolism,physiopathology Oncogenes/physiology Proto-Oncogene Proteins/metabolism Proto-Oncogene Proteins c-maf Receptors, CCR1 Receptors, Chemokine/metabolism Signal Transduction Vascular Endothelial Growth Factor A/metabolism

Chemicals

CCND2 protein, human CCR1 protein, human Cadherins Cyclin D2 Cyclins DNA-Binding Proteins Integrin beta Chains MAF protein, human Proto-Oncogene Proteins Proto-Oncogene Proteins c-maf Receptors, CCR1 Receptors, Chemokine VEGFA protein, human Vascular Endothelial Growth Factor A integrin beta7

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kienast Joachim

Department of Medicine, Hematology and Oncology, University of Muenster, D-48129 Muenster, Germany. kienast@uni-muenster.de

Berdel Wolfgang E

Article Info

Journal

Cancer cell

Abbr.

Cancer Cell

ISSN

1535-6108

DOI

10.1016/s1535-6108(04)00030-3

kienast@uni-muenster.de

Published

2004-02-00

Pages

109-10

Language

English

Region

United States

NLM ID

101130617

Subset

Corrections

CommentOn

PMID: 14998494

External Links

PubMed source DOI: 10.1016/s1535-6108(04)00030-3 View journal details

Analysis Services

c-maf in multiple myeloma: an oncogene enhancing tumor-stroma interactions.

Contact

WeChat Official Account