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PMID: 1497088 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Detection of the t(14;18) at similar frequencies in hyperplastic lymphoid tissues from American and Japanese patients.

The American journal of pathology ·Vol. 141 ·No. 2 ·1992-08-00 ·Pages 291-9

Aster JC, Kobayashi Y, Shiota M, Mori S, Sklar J

Abstract

Follicular lymphoma shows a wide geographic variation in incidence, occurring more frequently in the U.S. than in Japan. A translocation involving the bcl-2 gene on chromosome 18 and the immunoglobulin heavy chain gene on chromosome 14 is frequently found in follicular lymphomas and is believed to play a critical role in the pathogenesis of these tumors. Recently, bcl-2/IgH rearrangements have been detected in reactive lymphoid tissue obtained from European patients, indicating that such rearrangements occur at some low but measurable background rate. In non-malignant tissues, the polymerase chain reaction was used to study the frequency of bcl-2/IgH rearrangements in reactive lymphoid tissue obtained from American and Japanese patients to find out whether geographic variation in the incidence of follicular lymphoma was caused by differences in sporadic occurrence of the t(14;18). We found such rearrangements in 5 of 15 American hyperplastic tonsils and lymph nodes and 5 of 10 Japanese tonsils, an incidence close to that previously seen in European patients. These data suggest that the background incidence of such rearrangements is similar in all populations, regardless of the incidence of follicular lymphoma.

MeSH Terms
Adult Base Sequence Child Child, Preschool Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 18 Female Gene Rearrangement Humans Hyperplasia Lymphoid Tissue/pathology Lymphoma, Follicular/genetics Male Molecular Sequence Data Oligonucleotide Probes/genetics Polymerase Chain Reaction Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-bcl-2 Translocation, Genetic
Chemicals
Oligonucleotide Probes Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Aster J C
Division of Diagnostic Molecular Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Kobayashi Y
Shiota M
Mori S
Sklar J
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1992-08-00
Pages
291-9
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1886599
Subset
IM
Grants
NCI NIH HHS · CA 38621 · United States
External Links
PubMed source PMC Full Text View journal details
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