The relation of herpes virus to host cell mitochondria.
The intracellular distribution of herpes virus in embryonic liver was investigated. 80 per cent of the virus was found in the cytoplasm in what appears to be a form uncombined with mitochondria or nuclei. A significant amount of the virus (16 per cent) was found bound to the mitochondria by an intimate attachment. Furthermore evidence was obtained that the mitochondria from liver tissue undergo a selective deterioration when infected with herpes virus. The concept is advanced that these organelles function in the development of virus.
6 references, click to expand
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Cellular changes in the chick chorio-allantoic membrane infected with herpes simplex and vaccinia; a study with thin sections for the electron microscope.Bull Johns Hopkins Hosp. 1950 Dec;87(6):511-47 PMID: 14783718
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Cytochemical studies of mammalian tissues. III. Isocitric dehydrogenase and triphosphopyridine nucleotide-cytochrome c reductase of mouse liver.J Biol Chem. 1950 Oct;186(2):417-27 PMID: 14794638
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Concerning the relation of the Krebs cycle to virus propagation.J Biol Chem. 1951 Mar;189(1):421-8 PMID: 14832255
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The relation of the Krebs cycle to viral synthesis. II. The effect of sodium fluoroacetate on the propagation of influenza virus in mice.J Exp Med. 1951 Jun;93(6):635-42 PMID: 14832407
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Some biochemical aspects of herpes infection.Proc Soc Exp Biol Med. 1950 May;74(1):123-6 PMID: 15430409
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The relation of herpes virus to the cell nucleus.Yale J Biol Med. 1950 Jul;22(6):579-87 PMID: 15431688
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