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PMID: 1493081 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Co-regulation of phenytoin and tolbutamide metabolism in humans.

British journal of clinical pharmacology ·Vol. 34 ·No. 6 ·1992-12-00 ·Pages 494-8

Tassaneeyakul W, Veronese ME, Birkett DJ, Doecke CJ, McManus ME, Sansom LN, Miners JO

Abstract

1. The disposition of phenytoin and tolbutamide was compared in eighteen healthy young adults separately administered single therapeutic doses (sodium phenytoin 300 mg, tolbutamide 500 mg) of the two drugs. 2. Within the group, ratios of ranges of total and unbound areas under the plasma concentration-time curves were similar for both drugs. 3. There were significant (P < 0.001) correlations between total (r = 0.88) and unbound (r = 0.86) areas under the plasma phenytoin and tolbutamide concentration-time curves. 4. The results are consistent with the involvement of the same cytochrome P-450 isoenzyme(s) in the metabolism of tolbutamide and phenytoin.

MeSH Terms
Adult Blood Proteins/metabolism Chromatography, High Pressure Liquid Drug Interactions Female Humans Male Phenytoin/blood,pharmacokinetics Protein Binding Tolbutamide/blood,pharmacokinetics
Chemicals
Blood Proteins Phenytoin Tolbutamide
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Tassaneeyakul W
Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, South Australia.
Veronese M E
Birkett D J
Doecke C J
McManus M E
Sansom L N
Miners J O
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Article Info
Journal
British journal of clinical pharmacology
Abbr.
Br J Clin Pharmacol
ISSN
0306-5251
Published
1992-12-00
Pages
494-8
Language
English
Region
England
NLM ID
7503323
PMCID
PMC1381450
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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