Adaptation of a Lansing strain of poliomyelitis virus to newborn mice.
By means of rapid serial passages, including 3 successive "blind" passages, the MEF1 strain, a Lansing-type poliomyelitis virus, has been adapted to new-born mice. The virus can readily be propagated in newborn mice, in which fully adapted virus induces in almost all inoculated animals the experimental disease, resulting in a much greater infectivity for the central nervous system and a uniformly short and regular incubation period.
11 references, click to expand
-
Some observations on the pathogenesis of eastern equine encephalomyelitis and louping-ill in young and old animals, with special reference to routes of entry of the viruses into the nervous system.J Comp Pathol. 1950 Oct;60(4):237-62 PMID: 14814230
-
A complement-fixation test for poliomyelitis virus.Proc Soc Exp Biol Med. 1950 Nov;75(2):315-8 PMID: 14808245
-
Preservation of neurotropic viruses.U S Armed Forces Med J. 1950 Apr;1(4):415-7 PMID: 15413257
-
A MOUSE TEST FOR MEASURING THE IMMUNIZING POTENCY OF ANTIRABIES VACCINES.J Exp Med. 1939 Jun 30;70(1):87-106 PMID: 19870893
-
INFLUENCE OF AGE FACTORS ON SUSCEPTIBILITY OF MICE TO RABIES VIRUS.J Exp Med. 1940 Sep 30;72(4):445-51 PMID: 19871035
-
INTRAPERITONEAL AND INTRACEREBRAL ROUTES IN SERUM PROTECTION TESTS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS : I. A COMPARISON OF THE TWO ROUTES IN PROTECTION TESTS.J Exp Med. 1938 Jul 31;68(2):173-89 PMID: 19870781
-
Additional properties of the MEFI strain of poliomyelitis virus, especially with reference to attempts at cultivation in the chick embryo.J Bacteriol. 1949 Jul;58(1):112 PMID: 18151940
-
CONSTITUTIONAL BARRIERS TO INVOLVEMENT OF THE NERVOUS SYSTEM BY CERTAIN VIRUSES.Science. 1940 Jan 26;91(2352):84-7 PMID: 17809224
-
TRANSMISSION TO RODENTS OF LANSING TYPE POLIOMYELITIS VIRUS ORIGINATING IN THE MIDDLE EAST.Science. 1943 Nov 19;98(2551):452-4 PMID: 17750783
-
AN ACQUIRED RESISTANCE OF GROWING ANIMALS TO CERTAIN NEUROTROPIC VIRUSES IN THE ABSENCE OF HUMORAL ANTIBODIES OR PREVIOUS EXPOSURE TO INFECTION.J Exp Med. 1936 Oct 31;64(5):723-37 PMID: 19870564
-
INFLUENCE OF AGE ON SUSCEPTIBILITY AND ON IMMUNE RESPONSE OF MICE TO EASTERN EQUINE ENCEPHALOMYELITIS VIRUS.J Exp Med. 1941 Jul 31;74(2):115-32 PMID: 19871121
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
