Home LiteratureArticle Details
PMID: 148487 Published · ppublish English Journal Article

T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells.

The Journal of experimental medicine ·Vol. 147 ·No. 5 ·1978-05-01 ·Pages 1395-1404

Wettstein PJ, Bailey DW, Mobraaten LE, Klein J, Frelinger JA

Abstract

We have determined the Ly phenotype of the T lymphocytes which proliferate in response to mutant H-2K and H-2D alloantigens in primary mixed lymphocyte culture. Responder T cells proliferating in reciprocal cultures of H-2d(KdDd) and H-2da(KdDda) lymphocytes were typed Ly 2+ through selective depletion with specific alloantiserum plus complement. Further, B6-Ly 1a lymphocytes proliferating in response to B6-H-2ba and B6-H-2bf stimulators were typed as Ly 1+2+ through similar analysis. These results are discussed with regard to their impact on views of lymphocyte differentiation and factors determining the identity of alloreactive lymphocytes.

MeSH Terms
Animals Antigens Cytotoxicity Tests, Immunologic H-2 Antigens Immune Sera Lymphocyte Culture Test, Mixed Mice Mutation Phenotype T-Lymphocytes/immunology
Chemicals
Antigens H-2 Antigens Immune Sera
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Wettstein P J
Bailey D W
Mobraaten L E
Klein J
Frelinger J A
References (22)
22 references, click to expand
  1. Ly-4.2: a cell membrane alloantigen of murine B lymphocytes. I. Population studies.
    J Immunol. 1975 Feb;114(2 pt 2):848-55 PMID: 1078681
  2. Effects of anti-Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS, by specific anti-Ia sera.
    J Immunol. 1975 Dec;115(6):1672-6 PMID: 1081105
  3. Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses.
    J Exp Med. 1976 Jun 1;143(6):1382-90 PMID: 1083887
  4. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.
    J Exp Med. 1975 Jun 1;141(6):1376-89 PMID: 1092798
  5. Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.
    J Exp Med. 1975 Jun 1;141(6):1390-9 PMID: 1092799
  6. Immunogeneic analysis of H-2 mutations. II. Cellular immunity to the H-2DA mutation.
    J Immunol. 1975 Sep;115(3):711-5 PMID: 125300
  7. H-2 effects on cell-cell interactions in the response to single non-H-2 alloantigens. II. H-2D region control of H-7.1-specific stimulator function in mixed lymphocyte culture and susceptibility to lysis by H-7.1-specific cytotoxic cells.
    J Exp Med. 1977 Nov 1;146(5):1356-66 PMID: 144769
  8. Ly phenotype of T cells cytotoxic for syngeneic mouse mammary tumors: evidence for T cell interactions.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5667-71 PMID: 304579
  9. Mixed lymphocyte reaction caused by an H-2D mutation (congenic strains-B10.D2 new-B10.504).
    Folia Biol (Praha). 1972;18(5):360-3 PMID: 4117981
  10. Cell-mediated lympholysis. Importance of serologically defined H-2 regions.
    J Exp Med. 1973 May 1;137(5):1303-9 PMID: 4267208
  11. Lymphocyte reactivity to serologically undetected components of the major histocompatibility complex.
    Nat New Biol. 1973 Apr 25;242(121):239-41 PMID: 4267212
  12. A miniaturized mouse mixed leukocyte culture in serum-free and mouse serum supplemented media.
    J Immunol Methods. 1973 Oct;3(2):147-63 PMID: 4271080
  13. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.
    Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175-93 PMID: 4385242
  14. Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse.
    J Exp Med. 1972 Dec 1;136(6):1430-44 PMID: 4404878
  15. Ly-4, a new locus determining a lymphocyte cell-surface alloantigen in mice.
    Proc Natl Acad Sci U S A. 1973 Apr;70(4):1108-11 PMID: 4515607
  16. New lymphocyte antigen system (Lna) controlled by the Ir region of the mouse H-2 complex.
    Proc Natl Acad Sci U S A. 1973 Sep;70(9):2509-14 PMID: 4517664
  17. Immune responses in vitro. I. Culture conditions for antibody synthesis.
    Cell Immunol. 1972 Feb;3(2):264-76 PMID: 4551691
  18. Histoincompatibilities found between congenic strains which differ at loci determing differentiation antigens.
    Transplantation. 1973 Nov;16(5):505-14 PMID: 4584957
  19. A rapid method for the isolation of functional thymus-derived murine lymphocytes.
    Eur J Immunol. 1973 Oct;3(10):645-9 PMID: 4587740
  20. Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.
    Transplantation. 1971 Mar;11(3):351-3 PMID: 5558567
  21. Inherited histocompatibility changes in progeny of irradiated and unirradiated inbred mice.
    Genet Res. 1965 Nov;6(3):330-40 PMID: 5848712
  22. Ly phenotype of cytotoxic T cells for syngeneic tumor.
    J Exp Med. 1976 Oct 1;144(4):1116-20 PMID: 62011
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.147.5.1395
Published
1978-05-01
Pages
1395-1404
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2184279
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.147.5.1395 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2