Home LiteratureArticle Details
PMID: 1474963 Published · ppublish English Journal Article Review

Consequences of the interaction of beta-lactam antibiotics with penicillin binding proteins from sensitive and resistant Staphylococcus aureus strains.

Medical microbiology and immunology ·Vol. 181 ·No. 5 ·1992-00-00 ·Pages 241-65

Labischinski H

Abstract

暂无摘要

MeSH Terms
Amino Acid Sequence Bacterial Proteins Carbohydrate Sequence Carrier Proteins/metabolism Cell Wall/chemistry Hexosyltransferases Molecular Sequence Data Muramoylpentapeptide Carboxypeptidase/metabolism Penicillin Resistance Penicillin-Binding Proteins Penicillins/metabolism,pharmacology Peptidyl Transferases Polysaccharides, Bacterial/chemistry Staphylococcus aureus/drug effects,growth & development,ultrastructure
Chemicals
Bacterial Proteins Carrier Proteins Penicillin-Binding Proteins Penicillins Polysaccharides, Bacterial Peptidyl Transferases Hexosyltransferases Muramoylpentapeptide Carboxypeptidase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Labischinski H
Robert Koch-Institute of the Federal Health Organization, Berlin, Federal Republic of Germany.
References (105)
105 references, click to expand
  1. Cross-linking and O-acetylation of peptidoglycan in Staphylococcus aureus (strains H and MR-1) grown in the presence of sub-growth-inhibitory concentrations of beta-lactam antibiotics.
    J Gen Microbiol. 1991 Jul;137(7):1661-6 PMID: 1955858
  2. Terminology of Staphylococcus aureus strains showing decreased susceptibility to methicillin.
    J Antimicrob Chemother. 1992 Feb;29(2):219-21 PMID: 1506337
  3. Model for the structure of the shape-maintaining layer of the Escherichia coli cell envelope.
    J Bacteriol. 1973 Jun;114(3):1264-70 PMID: 4576404
  4. Localization of bacteriophage receptor, clumping factor, and protein A on the cell surface of Staphylococcus aureus.
    J Bacteriol. 1980 Feb;141(2):838-44 PMID: 6444946
  5. Penicillins and cephalosporins are active site-directed acylating agents: evidence in support of the substrate analogue hypothesis.
    Philos Trans R Soc Lond B Biol Sci. 1980 May 16;289(1036):257-71 PMID: 6109322
  6. Methicillin resistance in Staphylococcus epidermidis. Relationship between the additional penicillin-binding protein and an attachment transpeptidase.
    Eur J Biochem. 1989 Oct 20;185(1):211-8 PMID: 2806258
  7. Antimicrobial resistance of Staphylococcus aureus: genetic basis.
    Microbiol Rev. 1987 Mar;51(1):88-134 PMID: 3031442
  8. Clonal analysis of methicillin-resistant Staphylococcus aureus strains from intercontinental sources: association of the mec gene with divergent phylogenetic lineages implies dissemination by horizontal transfer and recombination.
    J Clin Microbiol. 1992 Aug;30(8):2058-63 PMID: 1500513
  9. Peptidoglycan composition of a highly methicillin-resistant Staphylococcus aureus strain. The role of penicillin binding protein 2A.
    J Biol Chem. 1992 Jun 5;267(16):11248-54 PMID: 1597460
  10. Autolytic release and osmotic properties of protoplasts from Staphylococcus aureus.
    J Gen Microbiol. 1957 Feb;16(1):184-94 PMID: 13406228
  11. In vitro synthesis and O acetylation of peptidoglycan by permeabilized cells of Proteus mirabilis.
    J Bacteriol. 1991 Aug;173(15):4618-24 PMID: 1856164
  12. Cell division in staphylococci: a clue to the three-dimensional structure of peptidoglycan.
    J Infect Dis. 1987 Mar;155(3):423-32 PMID: 3805769
  13. Peptidoglycan cross-linking and teichoic acid attachment in Streptococcus pneumoniae.
    J Bacteriol. 1985 Jul;163(1):46-54 PMID: 4008447
  14. Production of low-affinity penicillin-binding protein by low- and high-resistance groups of methicillin-resistant Staphylococcus aureus.
    Antimicrob Agents Chemother. 1987 Sep;31(9):1307-11 PMID: 3499861
  15. Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.
    Bacteriol Rev. 1974 Sep;38(3):291-335 PMID: 4608953
  16. Conversion of a homogeneously methicillin-resistant strain of Staphylococcus aureus to heterogeneous resistance by Tn551-mediated insertional inactivation.
    Eur J Clin Microbiol. 1986 Dec;5(6):714-8 PMID: 3026802
  17. Major trends in the microbial etiology of nosocomial infection.
    Am J Med. 1991 Sep 16;91(3B):72S-75S PMID: 1928195
  18. Neither an enhancement of autolytic wall degradation nor an inhibition of the incorporation of cell wall material are pre-requisites for penicillin-induced bacteriolysis in staphylococci.
    Arch Microbiol. 1985 May;141(4):309-14 PMID: 4015304
  19. The Enterococcus hirae R40 penicillin-binding protein 5 and the methicillin-resistant Staphylococcus aureus penicillin-binding protein 2' are similar.
    Biochem J. 1991 Dec 1;280 ( Pt 2):463-9 PMID: 1747121
  20. A biological price of antibiotic resistance: major changes in the peptidoglycan structure of penicillin-resistant pneumococci.
    Proc Natl Acad Sci U S A. 1990 Jul;87(14):5415-9 PMID: 2371278
  21. Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine.
    Proc Natl Acad Sci U S A. 1965 Oct;54(4):1133-41 PMID: 5219821
  22. Binding of beta-lactam antibiotics to penicillin-binding proteins of Staphylococcus aureus and Streptococcus faecalis: relation to antibacterial activity.
    Antimicrob Agents Chemother. 1980 Nov;18(5):834-6 PMID: 6778388
  23. Peptidoglycan types of bacterial cell walls and their taxonomic implications.
    Bacteriol Rev. 1972 Dec;36(4):407-77 PMID: 4568761
  24. BAGSHAPED MACROMOLECULES--A NEW OUTLOOK ON BACTERIAL CELL WALLS.
    Adv Enzymol Relat Subj Biochem. 1964;26:193-232 PMID: 14150645
  25. A special morphogenetic wall defect and the subsequent activity of "murosomes" as the very reason for penicillin-induced bacteriolysis in staphylococci.
    Arch Microbiol. 1985 May;141(4):315-24 PMID: 4015305
  26. Effects of growth of methicillin-resistant and -susceptible Staphylococcus aureus in the presence of beta-lactams on peptidoglycan structure and susceptibility to lytic enzymes.
    Antimicrob Agents Chemother. 1986 Feb;29(2):250-7 PMID: 2872855
  27. Immunological detection of penicillin-binding protein 2' in clinical isolates of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.
    FEMS Microbiol Lett. 1989 Jan 1;48(1):97-103 PMID: 2714634
  28. Stable classes of phenotypic expression in methicillin-resistant clinical isolates of staphylococci.
    Antimicrob Agents Chemother. 1991 Jan;35(1):124-9 PMID: 2014967
  29. Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion.
    FEBS Lett. 1987 Aug 31;221(1):167-71 PMID: 3305073
  30. Molecular cloning of the gene of a penicillin-binding protein supposed to cause high resistance to beta-lactam antibiotics in Staphylococcus aureus.
    J Bacteriol. 1986 Sep;167(3):975-80 PMID: 3638304
  31. New mechanisms of bacterial resistance to antimicrobial agents.
    N Engl J Med. 1991 Feb 28;324(9):601-12 PMID: 1992321
  32. Altered murein composition in a DD-carboxypeptidase mutant of Streptococcus pneumoniae.
    J Bacteriol. 1992 Aug;174(15):5152-5 PMID: 1629174
  33. Suppression of autolysis and cell wall turnover in heterogeneous Tn551 mutants of a methicillin-resistant Staphylococcus aureus strain.
    J Bacteriol. 1991 Feb;173(3):1105-10 PMID: 1846855
  34. Methicillin-resistant staphylococci.
    Clin Microbiol Rev. 1988 Apr;1(2):173-86 PMID: 3069195
  35. Influence of femB on methicillin resistance and peptidoglycan metabolism in Staphylococcus aureus.
    J Bacteriol. 1993 Mar;175(6):1612-20 PMID: 8383661
  36. O-acetylated peptidoglycan: its occurrence, pathobiological significance, and biosynthesis.
    Can J Microbiol. 1992 Feb;38(2):85-91 PMID: 1521192
  37. Intrinsic resistance to beta-lactam antibiotics in Staphylococcus aureus.
    FEBS Lett. 1980 Dec 29;122(2):275-8 PMID: 7202719
  38. Methicillin-resistant Staphylococcus aureus: microbiologic characteristics, antimicrobial susceptibilities, and assessment of virulence of an epidemic strain.
    J Infect Dis. 1981 Dec;144(6):575-82 PMID: 6977003
  39. Direct proof of a "more-than-single-layered" peptidoglycan architecture of Escherichia coli W7: a neutron small-angle scattering study.
    J Bacteriol. 1991 Jan;173(2):751-6 PMID: 1987162
  40. A membrane enzyme from Staphylococcus aureus which catalyzes transpeptidase, carboxypeptidase, and penicillinase activities.
    J Biol Chem. 1978 Feb 25;253(4):1272-8 PMID: 624730
  41. Lower autolytic activity in a homogeneous methicillin-resistant Staphylococcus aureus strain compared to derived heterogeneous-resistant and susceptible strains.
    FEMS Microbiol Lett. 1989 May;50(1-2):107-11 PMID: 2544481
  42. On the morphogenesis of the cell wall of staphylococci.
    Int Rev Cytol. 1976;44:225-318 PMID: 770370
  43. Altered muropeptide composition in Staphylococcus aureus strains with an inactivated femA locus.
    J Bacteriol. 1993 May;175(9):2779-82 PMID: 8478340
  44. Five independent combinations of mutations can result in low-affinity penicillin-binding protein 2x of Streptococcus pneumoniae.
    J Bacteriol. 1991 Nov;173(21):6986-90 PMID: 1938899
  45. The mechanism of the irreversible antimicrobial effects of penicillins: how the beta-lactam antibiotics kill and lyse bacteria.
    Annu Rev Microbiol. 1979;33:113-37 PMID: 40528
  46. Cell wall composition and associated properties of methicillin-resistant Staphylococcus aureus strains.
    J Bacteriol. 1978 Dec;136(3):976-82 PMID: 152758
  47. Penicillin-induced changes in the cell wall composition of Staphylococcus aureus before the onset of bacteriolysis.
    Arch Microbiol. 1990;154(1):73-81 PMID: 2396890
  48. Staphylococcus aureus and Micrococcus luteus peptidoglycan transglycosylases that are not penicillin-binding proteins.
    J Bacteriol. 1984 Feb;157(2):538-44 PMID: 6693351
  49. Comparative in vivo nitrogen-15 nuclear magnetic resonance study of the cell wall components of five Gram-positive bacteria.
    Biochemistry. 1979 Feb 20;18(4):704-14 PMID: 105756
  50. Fan-shaped ejections of regularly arranged murosomes involved in penicillin-induced death of staphylococci.
    J Bacteriol. 1992 Apr;174(7):2241-52 PMID: 1551845
  51. Structure, function, and assembly of cell walls of gram-positive bacteria.
    Annu Rev Microbiol. 1983;37:501-27 PMID: 6139058
  52. Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics.
    Annu Rev Biochem. 1983;52:825-69 PMID: 6351730
  53. New mechanism for methicillin resistance in Staphylococcus aureus: clinical isolates that lack the PBP 2a gene and contain normal penicillin-binding proteins with modified penicillin-binding capacity.
    Antimicrob Agents Chemother. 1989 Nov;33(11):1869-74 PMID: 2610497
  54. Mapping and characterization of multiple chromosomal factors involved in methicillin resistance in Staphylococcus aureus.
    Antimicrob Agents Chemother. 1992 Jul;36(7):1367-73 PMID: 1510429
  55. Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus.
    J Bacteriol. 1984 May;158(2):513-6 PMID: 6563036
  56. Cross-linking and O-acetylation of newly synthesized peptidoglycan in Staphylococcus aureus H.
    J Gen Microbiol. 1989 Nov;135(11):3015-22 PMID: 2614378
  57. Penicillins activate autolysins extracted from both Escherichia coli and Klebsiella pneumoniae envelopes.
    Antimicrob Agents Chemother. 1977 Dec;12(6):745-7 PMID: 337892
  58. The mechanism of development of resistance to lysozyme by some gram-positive bacteria and its results.
    Br J Exp Pathol. 1959 Oct;40:441-51 PMID: 13849207
  59. Biosynthesis of peptidoglycan in Gaffkya homari: on the target(s) of benzylpenicillin.
    Antimicrob Agents Chemother. 1991 Sep;35(9):1753-9 PMID: 1952843
  60. Structure of the peptidoglycan of bacterial cell wassl. II.
    J Mol Biol. 1977 Dec 25;117(4):955-74 PMID: 606840
  61. Beta-lactam-specific resistant mutants of Staphylococcus aureus.
    Antimicrob Agents Chemother. 1986 Oct;30(4):577-83 PMID: 3539012
  62. Peptidoglycan cross-linking in Staphylococcus aureus. An apparent random polymerisation process.
    Eur J Biochem. 1990 Jul 31;191(2):373-7 PMID: 2384086
  63. Role of an altered penicillin-binding protein in methicillin- and cephem-resistant Staphylococcus aureus.
    Antimicrob Agents Chemother. 1985 Sep;28(3):397-403 PMID: 3878127
  64. Onset of penicillin-induced bacteriolysis in staphylococci is cell cycle dependent.
    J Bacteriol. 1989 Apr;171(4):2252-7 PMID: 2703473
  65. Transduction of Methicillin Resistance in Staphylococcus aureus Dependent on an Unusual Specificity of the Recipient Strain.
    J Bacteriol. 1970 Dec;104(3):1158-67 PMID: 16559089
  66. Elasticity of the sacculus of Escherichia coli.
    J Bacteriol. 1992 Jul;174(14):4811-9 PMID: 1624468
  67. Experimental and clinical aspects of resistance determinants. Mode of resistance against beta-lactam antibiotics in staphylococci.
    Ann N Y Acad Sci. 1971 Jun 11;182:106-17 PMID: 5285286
  68. Infrared spectroscopy, a tool for probing bacterial peptidoglycan. Potentialities of infrared spectroscopy for cell wall analytical studies and rejection of models based on crystalline chitin.
    Eur J Biochem. 1982 Jul;125(3):505-15 PMID: 7117249
  69. Multiple mechanisms of methicillin resistance and improved methods for detection in clinical isolates of Staphylococcus aureus.
    Antimicrob Agents Chemother. 1991 Apr;35(4):632-9 PMID: 2069369
  70. On the secondary and tertiary structure of murein. Low and medium-angle X-ray evidence against chitin-based conformations of bacterial peptidoglycan.
    Eur J Biochem. 1979 Mar 15;95(1):147-55 PMID: 456346
  71. Synthesis of peptidoglycan in vivo in methicillin-resistant Staphylococcus aureus.
    Eur J Biochem. 1982 Oct;127(3):553-8 PMID: 7173195
  72. FtsZ and cell division.
    Res Microbiol. 1991 Feb-Apr;142(2-3):249-52 PMID: 1925024
  73. Conjugative transfer genes in staphylococcal isolates from the United States.
    Antimicrob Agents Chemother. 1991 Dec;35(12):2500-4 PMID: 1810183
  74. Conformational and topological aspects of the three-dimensional architecture of bacterial peptidoglycan.
    Ann Inst Pasteur Microbiol (1985). 1985 Jan-Feb;136A(1):45-50 PMID: 4004147
  75. Dependence of lysozyme-catalysed solubilization of Proteus mirabilis peptidoglycan on the extent of O-acetylation.
    Eur J Biochem. 1991 Feb 14;195(3):763-9 PMID: 1999194
  76. Ultrastructural localization of carbohydrates on thin sections of Staphylococcus aureus with silver methenamine and wheat germ agglutinin-gold complex.
    J Bacteriol. 1987 Mar;169(3):1358-62 PMID: 2434460
  77. Insertional inactivation of staphylococcal methicillin resistance by Tn551.
    J Bacteriol. 1983 Apr;154(1):479-87 PMID: 6300037
  78. Presence of an additional penicillin-binding protein in methicillin-resistant Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, and Staphylococcus simulans with a low affinity for methicillin, cephalothin, and cefamandole.
    Antimicrob Agents Chemother. 1990 Sep;34(9):1691-4 PMID: 2285281
  79. Methicillin-resistant staphylococci: genetics and mechanisms of resistance.
    Antimicrob Agents Chemother. 1989 Jul;33(7):991-4 PMID: 2675759
  80. Characterization of penicillin-binding protein 2 of Staphylococcus aureus: deacylation reaction and identification of two penicillin-binding peptides.
    Antimicrob Agents Chemother. 1992 Mar;36(3):656-61 PMID: 1622180
  81. Conjugative transfer of staphylococcal antibiotic resistance markers in the absence of detectable plasmid DNA.
    Antimicrob Agents Chemother. 1986 Jul;30(1):161-9 PMID: 2944478
  82. Characterization of an isogenic set of methicillin-resistant and susceptible mutants of Staphylococcus aureus.
    Eur J Clin Microbiol. 1986 Dec;5(6):697-701 PMID: 3026801
  83. Possible physiological functions of penicillin-binding proteins in Staphylococcus aureus.
    Antimicrob Agents Chemother. 1986 Feb;29(2):333-6 PMID: 3521479
  84. Resistance of O-acetylated gonococcal peptidoglycan to human peptidoglycan-degrading enzymes.
    Infect Immun. 1983 Jun;40(3):903-11 PMID: 6406367
  85. Multiple penicillin-binding components in Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Escherichia coli.
    J Biol Chem. 1972 Sep 10;247(17):5279-88 PMID: 4626716
  86. Dual enzyme activities of cell wall peptidoglycan synthesis, peptidoglycan transglycosylase and penicillin-sensitive transpeptidase, in purified preparations of Escherichia coli penicillin-binding protein 1A.
    Biochem Biophys Res Commun. 1980 Nov 17;97(1):287-93 PMID: 7006606
  87. Chemical and molecular classification of staphylococci.
    Soc Appl Bacteriol Symp Ser. 1990;19:9S-24S PMID: 2119069
  88. Serine beta-lactamases and penicillin-binding proteins.
    Annu Rev Microbiol. 1991;45:37-67 PMID: 1741619
  89. Natural methicillin resistance in comparison with that selected by in-vitro drug exposure in Staphylococcus aureus.
    J Antimicrob Chemother. 1989 Feb;23(2):179-88 PMID: 2708178
  90. Electromechanical interactions in cell walls of gram-positive cocci.
    J Bacteriol. 1970 Jan;101(1):92-101 PMID: 5411760
  91. Further characterization of borderline methicillin-resistant Staphylococcus aureus and analysis of penicillin-binding proteins.
    Antimicrob Agents Chemother. 1990 May;34(5):911-3 PMID: 2360829
  92. Effects of beta-lactam antibiotics on peptidoglycan synthesis in growing Neisseria gonorrhoeae, including changes in the degree of O-acetylation.
    J Bacteriol. 1981 Aug;147(2):633-41 PMID: 6790518
  93. Modification of peptidoglycan structure by penicillin action in cell walls of Proteus mirabilis.
    Eur J Biochem. 1979 Apr;95(3):487-95 PMID: 221218
  94. Biochemical and genetical approaches to the mechanism of action of penicillin.
    Philos Trans R Soc Lond B Biol Sci. 1980 May 16;289(1036):273-83 PMID: 6109323
  95. Conformational behavior of the polysaccharide backbone of murein.
    Biopolymers. 1987 Aug;26(8):1391-406 PMID: 3663868
  96. Cell division and peptidoglycan assembly in Escherichia coli.
    Mol Microbiol. 1991 Apr;5(4):791-5 PMID: 1649945
  97. Methicillin-resistant septal peptidoglycan synthesis in a methicillin-resistant Staphylococcus aureus strain.
    Antimicrob Agents Chemother. 1983 Apr;23(4):610-3 PMID: 6552895
  98. Isolation and characterization of a Tn551-autolysis mutant of Staphylococcus aureus.
    J Bacteriol. 1992 Aug;174(15):4952-9 PMID: 1321119
  99. Arrangement of peptidoglycan in the cell wall of Staphylococcus spp.
    J Bacteriol. 1982 May;150(2):844-50 PMID: 7068534
  100. Trapping of the substrate-derived acyl enzyme intermediate of purified penicillin-binding protein 1a of Escherichia coli.
    J Bacteriol. 1984 Nov;160(2):824-5 PMID: 6389502
  101. Methicillin-resistant Staphylococcus aureus.
    N Engl J Med. 1989 May 4;320(18):1188-96 PMID: 2651925
  102. Penicillin-binding proteins in beta-lactam-resistant laboratory mutants of Streptococcus pneumoniae.
    Mol Microbiol. 1987 Nov;1(3):355-63 PMID: 3448464
  103. femA, which encodes a factor essential for expression of methicillin resistance, affects glycine content of peptidoglycan in methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains.
    J Bacteriol. 1991 Jun;173(11):3507-13 PMID: 2045371
  104. Binding of beta-lactam antibiotics to penicillin-binding proteins in methicillin-resistant Staphylococcus aureus.
    J Infect Dis. 1990 Jun;161(6):1170-6 PMID: 2345297
  105. Antibiotic tolerance among clinical isolates of bacteria.
    Rev Infect Dis. 1985 May-Jun;7(3):368-86 PMID: 3895353
Article Info
Journal
Medical microbiology and immunology
Abbr.
Med Microbiol Immunol
ISSN
0300-8584
DOI
10.1007/BF00198846
Published
1992-00-00
Pages
241-65
Language
English
Region
Germany
NLM ID
0314524
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00198846 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2