Abstract
Type I PIPkins (phosphatidylinositol 4-phosphate 5-kinases) are the enzymes that catalyse the major cellular route of synthesis of PtdIns(4,5) P2, and three isoforms (alpha, beta and gamma) with several splice variants have been found to date. In the present paper, we describe the discovery of a novel splice variant of the gamma isoform, which we call PIPkin Igammac, and which is characterized by the inclusion of a 26-amino-acid insert near the C-terminus. Its transcript appears to be selectively expressed in brain, where it locates in the neurons of restricted regions, such as cerebellum, hippocampus, cortex and olfactory bulb, as indicated by in situ hybridization studies. Overexpression of two different catalytically inactive constructs of PIPkin Igammac in rat cerebellar granule cells causes a progressive loss of their neuronal processes, whereas equivalent kinase-dead versions of PIPkin Igammaa did not induce any such effect, suggesting the possible existence of a specific PtdIns(4,5) P2 pool synthesized by PIPkin Igammac, which is involved in the maintenance of some neuronal cellular processes.
MeSH Terms
Alternative Splicing
Amino Acid Sequence
Animals
Brain/cytology,enzymology
DNA, Complementary/isolation & purification
In Situ Hybridization
Isoenzymes/genetics,metabolism
Mice
Molecular Sequence Data
Neurons/cytology,enzymology
Phosphotransferases (Alcohol Group Acceptor)/genetics,metabolism,physiology
RNA, Messenger/analysis,metabolism
Rats
Sequence Homology, Amino Acid
Chemicals
DNA, Complementary
Isoenzymes
RNA, Messenger
Phosphotransferases (Alcohol Group Acceptor)
1-phosphatidylinositol-4-phosphate 5-kinase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Giudici Maria-Luisa
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.
Emson Piers C
Irvine Robin F
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