Hedgehog signaling: Costal-2 bridges the transduction gap.

Current biology : CB ·Vol. 14 ·No. 2 ·2004-01-20 ·Pages R67-9

Kalderon D

Abstract

Drosophila genetics has provided the Hedgehog signaling pathway with roughly ordered components, but few mechanistic connections. Several studies now show that the kinesin-related protein Costal-2 provides a physical link between the transmembrane transducer Smoothened and the transcriptional effector Cubitus interruptus.

MeSH Terms

Animals DNA-Binding Proteins/metabolism Drosophila/genetics,metabolism Drosophila Proteins/metabolism Hedgehog Proteins Kinesins/metabolism Models, Biological Receptors, G-Protein-Coupled/metabolism Signal Transduction Smoothened Receptor Transcription Factors

Chemicals

DNA-Binding Proteins Drosophila Proteins Hedgehog Proteins Receptors, G-Protein-Coupled Smoothened Receptor Transcription Factors ci protein, Drosophila cos protein, Drosophila smo protein, Drosophila hh protein, Drosophila Kinesins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Kalderon Daniel

Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/j.cub.2003.12.047

Published

2004-01-20

Pages

R67-9

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/j.cub.2003.12.047 View journal details

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