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PMID: 147301 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Transplantation tolerance in adult rats using total lymphoid irradiation: permanent survival of skin, heart, and marrow allografts.

The Journal of experimental medicine ·Vol. 147 ·No. 3 ·1978-03-01 ·Pages 700-7

Slavin S, Reitz B, Bieber CP, Kaplan HS, Strober S

Abstract

Lewis rats given total lymphoid irradiation (TLI) accepted bone marrow allografts from AgB-incompatible donors. The chimeras showed no clinical signs of graft-versus-host disease. Skin allografts from the marrow donor strain survived for more than 150 days on the chimeras. However, third-party skin grafts were rejected promptly. Although heart allografts survived more than 300 days in Lewis recipients given TLI and bone marrow allografts, detectable levels of chimerism were not required for permanent survival.

MeSH Terms

Animals Bone Marrow Transplantation Chimera Graft Rejection/radiation effects Graft vs Host Disease/prevention & control Heart Transplantation Immune Tolerance Lymphocyte Culture Test, Mixed Lymphoid Tissue/radiation effects Male Rats Skin Transplantation Transplantation, Homologous

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Slavin S

Reitz B

Bieber C P

Kaplan H S

Strober S

References (10)

10 references, click to expand

Bone marrow transplantation in rats across strong histocompatibility barriers by selective elimination of lymphoid cells in donor marrow.
Transplant Proc. 1976 Dec;8(4):537-41 PMID: 11584
Specific transplantation tolerance induced by autoimmunization against the individual's own, naturally occurring idiotypic, antigen-binding receptors.
J Exp Med. 1976 Dec 1;144(6):1438-57 PMID: 12245
Use of total lymphoid irradiation in tissue transplantation in mice.
Transplant Proc. 1977 Mar;9(1):1001-4 PMID: 141119
Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts.
J Exp Med. 1977 Jul 1;146(1):34-48 PMID: 17647
The induction and abolition of specific immunosuppression of heart allografts in rats by use of donor blood and cyclophosphamide.
J Immunol. 1975 Aug;115(2):405-8 PMID: 239060
Long-term survival of cardiac allografts in lethally irradiated rats repopulated with host-type hemopoietic cells.
Transplantation. 1975 Apr;19(4):295-301 PMID: 239473
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.
Scand J Clin Lab Invest Suppl. 1968;97:77-89 PMID: 4179068
Differential survival of heart and skin allografts in inbred rats.
Transplant Proc. 1973 Mar;5(1):717-9 PMID: 4572131
Improved technique of heart transplantation in rats.
J Thorac Cardiovasc Surg. 1969 Feb;57(2):225-9 PMID: 4884735
Long-term survival of skin allografts in mice treated with fractionated total lymphoid irradiation.
Science. 1976 Sep 24;193(4259):1252-4 PMID: 785599

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.147.3.700

Published

1978-03-01

Pages

700-7

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2184184

Subset

External Links

PubMed source DOI: 10.1084/jem.147.3.700 PMC Full Text View journal details

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Transplantation tolerance in adult rats using total lymphoid irradiation: permanent survival of skin, heart, and marrow allografts.

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