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PMID: 14729569 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

p63 is the molecular switch for initiation of an epithelial stratification program.

Genes & development ·Vol. 18 ·No. 2 ·2004-01-15 ·Pages 126-31

Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR

Abstract

Development of stratified epithelia, such as the epidermis, requires p63 expression. The p63 gene encodes isoforms that contain (TA) or lack (DeltaN) a transactivation domain. We demonstrate that TAp63 isoforms are the first to be expressed during embryogenesis and are required for initiation of epithelial stratification. In addition, TAp63 isoforms inhibit terminal differentiation, suggesting that TAp63 isoforms must be counterbalanced by DeltaNp63 isoforms to allow cells to respond to signals required for maturation of embryonic epidermis. Our data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis.

MeSH Terms
Animals Cell Differentiation/physiology Epithelium/embryology Keratinocytes/metabolism Mice Mice, Transgenic Phosphoproteins/genetics,metabolism Skin/embryology,metabolism Trans-Activators/genetics,metabolism
Chemicals
Phosphoproteins Trans-Activators Trp63 protein, mouse
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Koster Maranke I
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Kim Soeun
Mills Alea A
DeMayo Francesco J
Roop Dennis R
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.1165104
Published
2004-01-15
Epub
2004-00-16
Pages
126-31
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC324418
Subset
IM
Grants
NIAMS NIH HHS · AR 47898 · United States
NCI NIH HHS · CA 52607 · United States
NICHD NIH HHS · HD 25479 · United States
NIAMS NIH HHS · P01 AR047898 · United States
NHLBI NIH HHS · HL 61406 · United States
NCI NIH HHS · R01 CA052607 · United States
Corrections
CommentIn
PMID: 15037544
External Links
PubMed source DOI: 10.1101/gad.1165104 PMC Full Text View journal details
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