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PMID: 14722607 Published · ppublish English Journal Article Review

Bmi1, stem cells, and senescence regulation.

The Journal of clinical investigation ·Vol. 113 ·No. 2 ·2004-01-00 ·Pages 175-9

Park IK, Morrison SJ, Clarke MF

Abstract

Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.

MeSH Terms
Animals Cell Line Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16/metabolism Gene Expression Regulation Humans Mice Models, Biological Mutation Nuclear Proteins/genetics,metabolism,physiology Polycomb Repressive Complex 1 Proto-Oncogene Proteins/genetics,metabolism,physiology Repressor Proteins Stem Cells/metabolism Tumor Suppressor Protein p14ARF/metabolism
Chemicals
BMI1 protein, human Bmi1 protein, mouse Cdkn2a protein, mouse Cyclin-Dependent Kinase Inhibitor p16 Nuclear Proteins Proto-Oncogene Proteins Repressor Proteins Tumor Suppressor Protein p14ARF Polycomb Repressive Complex 1
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Park In-Kyung
Department of Internal Medicine, University of Michigan, School of Medicine, Ann Arbor, 48109, USA.
Morrison Sean J
Clarke Michael F
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI20800
Published
2004-01-00
Pages
175-9
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC311443
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI20800 PMC Full Text View journal details
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