14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins.

Trends in biochemical sciences ·Vol. 17 ·No. 12 ·1992-12-00 ·Pages 498-501

Aitken A, Collinge DB, van Heusden BP, Isobe T, Roseboom PH, Rosenfeld G, Soll J

Abstract

A family of proteins known as 14-3-3 is currently receiving increased attention by investigators studying a broad range of biological systems, including plants and invertebrates. The outstanding feature of this family is the extraordinarily high sequence conservation observed. Current thinking indicates that these proteins may function as regulators in signal transduction/phosphorylation mechanisms.

MeSH Terms

14-3-3 Proteins Amino Acid Sequence Animals Conserved Sequence Eukaryotic Cells/physiology Humans Molecular Sequence Data Nerve Tissue Proteins/chemistry,physiology Phosphorylation Plants Protein Kinase C/antagonists & inhibitors Signal Transduction Tyrosine 3-Monooxygenase

Chemicals

14-3-3 Proteins Nerve Tissue Proteins Tyrosine 3-Monooxygenase Protein Kinase C

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Aitken A

Laboratory of Protein Structure, National Institute for Medical Research, Mill Hill, London, UK.

Collinge D B

van Heusden B P

Isobe T

Roseboom P H

Rosenfeld G

Soll J

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/0968-0004(92)90339-b

Published

1992-12-00

Pages

498-501

Language

English

Region

England

NLM ID

7610674

Subset

External Links

PubMed source DOI: 10.1016/0968-0004(92)90339-b View journal details

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14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins.

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