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PMID: 14686326 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Characterization of HIV type 1 heterosexual transmission in Yunnan, China.

AIDS research and human retroviruses ·Vol. 19 ·No. 11 ·2003-11-00 ·Pages 1051-5

Yu XF, Wang X, Mao P, Wang S, Li Z, Zhang J, Garten R, Kong W, Lai S

Abstract

The earliest HIV-1 epidemic in China started in Yunnan province, which continues to be one of the most severe areas affected. While HIV-1 infections are spreading rapidly among injection drug users (IDUs) in China, sexual transmission of HIV-1 has also been confirmed, threatening the general population. Recent survey data indicated that heterosexual transmission of HIV-1 in Yunnan was steadily increasing. Diverse HIV-1 strains, including subtype B, C, CRF01, and CRF08, are circulating among individuals who acquired HIV through sexual contacts. Multiple HIV-1 subtypes, including subtypes B, C, and CRF08, were also detected among IDUs. In comparison with other IDU cohorts, intersubject env sequence variation was much higher amongIDUs in Yunnan. Growing evidence suggests that unprotected sex continues to occur at high rates among IDUs and their sex partners. Intervention strategies are urgently needed to target individuals at high risk for HIV heterosexual transmission and injection drug use. The complex pattern of HIV-1 distribution in the high-risk populations in Yunnan may have important implications for HIV transmission as well as vaccine development and evaluation.

MeSH Terms
China/epidemiology Female HIV Infections/epidemiology,transmission,virology HIV-1/classification,genetics Heterosexuality Humans Male Molecular Sequence Data Prevalence Sequence Analysis, DNA Sexual Behavior Substance Abuse, Intravenous/complications
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Yu Xiao-Fang
Department of Molecular Microbiology and Immunology, Johns Hopkins Univesity Bloomberg School of Public Health, Baltimore, Maryland 21205, USA. xfyu@jhsph.edu
Wang Xueren
Mao Penyong
Wang Shiyi
Li Zong
Zhang Jinbing
Garten Rebecca
Kong Wei
Lai Shenghan
Article Info
Journal
AIDS research and human retroviruses
Abbr.
AIDS Res Hum Retroviruses
ISSN
0889-2229
DOI
10.1089/088922203322588422
Email
xfyu@jhsph.edu
Published
2003-11-00
Pages
1051-5
Language
English
Region
United States
NLM ID
8709376
Subset
IM
Grants
NIDA NIH HHS · DA12327 · United States
NIDA NIH HHS · DA13918 · United States
Databases
GENBANK
AY339795, AY339796, AY339797, AY339798, AY339799, AY339800, AY339801, AY339802, AY339803, AY339804, AY339805, AY339806, AY339807, AY339808, AY339809, AY339810, AY339811, AY339812, AY339813, AY339814, AY339815, AY339816, AY339817, AY339818, AY339819
External Links
PubMed source DOI: 10.1089/088922203322588422 View journal details
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