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PMID: 14657490 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants.

Science (New York, N.Y.) ·Vol. 302 ·No. 5651 ·2003-12-05 ·Pages 1725

Tonkin LA, Bass BL

Abstract

暂无摘要

MeSH Terms
Adenosine Deaminase/genetics,physiology Animals Caenorhabditis elegans/genetics,physiology Caenorhabditis elegans Proteins/genetics,physiology Chemotaxis Crosses, Genetic Mutation RNA Editing RNA Interference RNA, Double-Stranded/metabolism RNA, Helminth/metabolism RNA-Binding Proteins/genetics,physiology
Chemicals
Caenorhabditis elegans Proteins RDE-4 protein, C elegans RNA, Double-Stranded RNA, Helminth RNA-Binding Proteins rde-1 protein, C elegans ADARB1 protein, human Adenosine Deaminase Adr-1 protein, C elegans Adr-2 protein, C elegans
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tonkin Leath A
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, 20 North 1900 East, Salt Lake City, UT 84132-3201, USA.
Bass Brenda L
References (12)
12 references, click to expand
  1. Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans.
    RNA. 2001 Oct;7(10):1397-402 PMID: 11680844
  2. Long RNA hairpins that contain inosine are present in Caenorhabditis elegans poly(A)+ RNA.
    Proc Natl Acad Sci U S A. 1999 May 25;96(11):6048-53 PMID: 10339539
  3. RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans.
    EMBO J. 2002 Nov 15;21(22):6025-35 PMID: 12426375
  4. The role of RNA editing by ADARs in RNAi.
    Mol Cell. 2002 Oct;10(4):809-17 PMID: 12419225
  5. Widespread occurrence of antisense transcription in the human genome.
    Nat Biotechnol. 2003 Apr;21(4):379-86 PMID: 12640466
  6. The rde-1 gene, RNA interference, and transposon silencing in C. elegans.
    Cell. 1999 Oct 15;99(2):123-32 PMID: 10535731
  7. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2.
    Nature. 2000 Jul 6;406(6791):78-81 PMID: 10894545
  8. A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity.
    Cell. 2000 Aug 18;102(4):437-49 PMID: 10966106
  9. Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis.
    Science. 2000 Dec 1;290(5497):1765-8 PMID: 11099415
  10. RNA editing by adenosine deaminases that act on RNA.
    Annu Rev Biochem. 2002;71:817-46 PMID: 12045112
  11. RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA.
    Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7906-11 PMID: 12048240
  12. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans.
    Cell. 2002 Jun 28;109(7):861-71 PMID: 12110183
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1091340
Published
2003-12-05
Pages
1725
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC1850956
Subset
IM
Grants
NIGMS NIH HHS · R01 GM044073 · United States
NIGMS NIH HHS · GM44073 · United States
External Links
PubMed source DOI: 10.1126/science.1091340 PMC Full Text View journal details
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