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PMID: 1463013 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, Minnesota. II. Regression relationships with concomitants.

American journal of human genetics ·Vol. 51 ·No. 6 ·1992-12-00 ·Pages 1311-24

Reilly SL, Ferrell RE, Kottke BA, Sing CF

Abstract

The influence of the apolipoprotein E (Apo E) polymorphism and gender on the regression relationships between each of nine plasma lipid and apolipoprotein traits (total cholesterol; ln triglycerides; high-density-lipoprotein cholesterol; apolipoproteins AI, AII, B, and CII; ln CIII; and ln E) and four concomitants (age, weight, waist-to-hip ratio, and smoking) was studied in 507 unrelated individuals representative of the adult population of Rochester, MN. Analyses are presented separately for females and males. Each lipid and apolipoprotein trait exhibited at least one Apo E genotype-specific regression relationship with the concomitants investigated in this study. In most cases the heterogeneity of regression was associated with differences between the epsilon 32 and epsilon 33 genotype. This study documents that the influence of Apo E genotype on average levels of plasma lipids and apolipoproteins varies among subdivisions of the population defined by age, body size, and smoking status.

MeSH Terms
Adult Age Factors Apolipoproteins/blood Apolipoproteins E/genetics Body Constitution Female Genotype Humans Lipids/blood Male Minnesota Polymorphism, Genetic Regression Analysis Sex Characteristics Sex Factors Smoking
Chemicals
Apolipoproteins Apolipoproteins E Lipids
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Reilly S L
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109-0618.
Ferrell R E
Kottke B A
Sing C F
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1992-12-00
Pages
1311-24
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1682931
Subset
IM
Grants
NHLBI NIH HHS · HL24489 · United States
NHLBI NIH HHS · HL30428 · United States
NHLBI NIH HHS · HL39107 · United States
External Links
PubMed source PMC Full Text View journal details
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