Home LiteratureArticle Details
PMID: 14617669 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

The phosphotransferase system of Streptomyces coelicolor is biased for N-acetylglucosamine metabolism.

Journal of bacteriology ·Vol. 185 ·No. 23 ·2003-12-00 ·Pages 7019-23

Nothaft H, Dresel D, Willimek A, Mahr K, Niederweis M, Titgemeyer F

Abstract

Mutation of the crr-ptsI gene locus revealed that Streptomyces coelicolor uses the phosphotransferase system (PTS) for N-acetylglucosamine uptake. crr, ptsI, and ptsH, which encode the three general PTS phosphotransferases, are induced by N-acetylglucosamine but not by other PTS substrates. Thus, the S. coelicolor PTS is biased for N-acetylglucosamine utilization, a novel feature that distinguishes this PTS from others.

MeSH Terms
Acetylglucosamine/metabolism Genes, Bacterial Mutation Phosphotransferases/genetics,metabolism Streptomyces/metabolism Substrate Specificity
Chemicals
Phosphotransferases Acetylglucosamine
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Nothaft Harald
Lehrstuhl für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91058 Erlangen, Germany.
Dresel Dagmar
Willimek Andreas
Mahr Kerstin
Niederweis Michael
Titgemeyer Fritz
References (28)
28 references, click to expand
  1. Quantitative analysis of gene expression with an improved green fluorescent protein. p6.
    Eur J Biochem. 2000 Mar;267(6):1565-70 PMID: 10712585
  2. Nitrogen metabolism in Streptomyces coelicolor A3(2): modification of glutamine synthetase I by an adenylyltransferase.
    Microbiology. 1999 Sep;145 ( Pt 9):2313-22 PMID: 10517584
  3. Negative control of rpoS expression by phosphoenolpyruvate: carbohydrate phosphotransferase system in Escherichia coli.
    J Bacteriol. 2001 Jan;183(2):520-7 PMID: 11133945
  4. Corynebacterium glutamicum: a dissection of the PTS.
    J Mol Microbiol Biotechnol. 2001 Jul;3(3):423-8 PMID: 11361073
  5. Sugar uptake and utilisation in Streptomyces coelicolor: a PTS view to the genome.
    Antonie Van Leeuwenhoek. 2000 Dec;78(3-4):243-51 PMID: 11386346
  6. Recognition and degradation of chitin by streptomycetes.
    Antonie Van Leeuwenhoek. 2001 Sep;79(3-4):285-9 PMID: 11816971
  7. Induction of the Bacillus subtilis ptsGHI operon by glucose is controlled by a novel antiterminator, GlcT.
    Mol Microbiol. 1997 Jul;25(1):65-78 PMID: 11902727
  8. Regulation of gene expression in the PTS in Escherichia coli: the role and interactions of Mlc.
    Curr Opin Microbiol. 2002 Apr;5(2):187-93 PMID: 11934616
  9. The phosphotransferase system of Streptomyces coelicolor.
    Eur J Biochem. 2002 Apr;269(8):2143-50 PMID: 11985592
  10. Streptomyces olivaceoviridis possesses a phosphotransferase system that mediates specific, phosphoenolpyruvate-dependent uptake of N-acetylglucosamine.
    Mol Genet Genomics. 2002 Nov;268(3):344-51 PMID: 12436256
  11. In vivo analysis of HPr reveals a fructose-specific phosphotransferase system that confers high-affinity uptake in Streptomyces coelicolor.
    J Bacteriol. 2003 Feb;185(3):929-37 PMID: 12533468
  12. Determination of the levels of HPr and enzyme I of the phosphoenolpyruvate-sugar phosphotransferase system in Escherichia coli and Salmonella typhimurium.
    Can J Biochem Cell Biol. 1983 Jan;61(1):29-37 PMID: 6406017
  13. Phosphoenolpyruvate:sugar phosphotransferase system of Bacillus subtilis: cloning of the region containing the ptsH and ptsI genes and evidence for a crr-like gene.
    J Bacteriol. 1987 May;169(5):2287-90 PMID: 3106335
  14. Sugar transport by the bacterial phosphotransferase system. Molecular cloning and structural analysis of the Escherichia coli ptsH, ptsI, and crr genes.
    J Biol Chem. 1987 Nov 25;262(33):16241-53 PMID: 2960675
  15. The ptsH, ptsI, and crr genes of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system: a complex operon with several modes of transcription.
    J Bacteriol. 1988 Sep;170(9):3827-37 PMID: 2457575
  16. Starvation-induced stimulation of sugar uptake in Streptococcus mutans is due to an effect on the activities of preexisting proteins of the phosphotransferase system.
    Infect Immun. 1988 Oct;56(10):2594-600 PMID: 3417351
  17. pACYC184-derived cloning vectors containing the multiple cloning site and lacZ alpha reporter gene of pUC8/9 and pUC18/19 plasmids.
    Gene. 1988 Aug 15;68(1):159-62 PMID: 2851489
  18. Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus).
    J Bacteriol. 1989 Nov;171(11):5872-81 PMID: 2681144
  19. Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector.
    Gene. 1992 Feb 1;111(1):61-8 PMID: 1547955
  20. Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.
    Microbiol Rev. 1993 Sep;57(3):543-94 PMID: 8246840
  21. New multifunctional Escherichia coli-Streptomyces shuttle vectors allowing blue-white screening on XGal plates.
    Gene. 1995 Nov 7;165(1):149-50 PMID: 7489909
  22. A lipid-anchored binding protein is a component of an ATP-dependent cellobiose/cellotriose-transport system from the cellulose degrader Streptomyces reticuli.
    Eur J Biochem. 1996 Dec 1;242(2):332-8 PMID: 8973652
  23. Direct repeat sequences in the Streptomyces chitinase-63 promoter direct both glucose repression and chitin induction.
    Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13116-21 PMID: 9371809
  24. High-multiplicity of chitinase genes in Streptomyces coelicolor A3(2).
    Biosci Biotechnol Biochem. 1999 Apr;63(4):710-8 PMID: 10361684
  25. Enzyme I(Ntr) from Escherichia coli. A novel enzyme of the phosphoenolpyruvate-dependent phosphotransferase system exhibiting strict specificity for its phosphoryl acceptor, NPr.
    J Biol Chem. 1999 Sep 10;274(37):26185-91 PMID: 10473571
  26. Analysis of a ptsH homologue from Streptomyces coelicolor A3(2).
    FEMS Microbiol Lett. 1999 Aug 15;177(2):279-88 PMID: 10474194
  27. The phosphotransferase system (PTS) of Streptomyces coelicolor identification and biochemical analysis of a histidine phosphocarrier protein HPr encoded by the gene ptsH.
    Eur J Biochem. 1999 Oct 1;265(1):308-17 PMID: 10491187
  28. Fructose utilization and phytopathogenicity of Spiroplasma citri.
    Mol Plant Microbe Interact. 2000 Oct;13(10):1145-55 PMID: 11043476
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.185.23.7019-7023.2003
Published
2003-12-00
Pages
7019-23
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC262694
Subset
IM
External Links
PubMed source DOI: 10.1128/JB.185.23.7019-7023.2003 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2