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PMID: 1458760 Published · ppublish English Journal Article Review

The role of pharmacokinetics in the development of biotechnologically derived agents.

Clinical pharmacokinetics ·Vol. 23 ·No. 6 ·1992-12-00 ·Pages 406-14

Wills RJ, Ferraiolo BL

Abstract

暂无摘要

MeSH Terms
Animals Antibodies/immunology Biotechnology Carrier Proteins/metabolism Drug Interactions Humans Peptides/administration & dosage,immunology,pharmacokinetics Proteins/administration & dosage,immunology,pharmacokinetics Species Specificity
Chemicals
Antibodies Carrier Proteins Peptides Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wills R J
Department of Drug Metabolism, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey.
Ferraiolo B L
References (50)
50 references, click to expand
  1. Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1-40). Evidence for intermittent somatostatin secretion.
    J Clin Invest. 1985 May;75(5):1584-90 PMID: 2860126
  2. Pharmacokinetics, single-dose tolerance, and biological activity of recombinant gamma-interferon in cancer patients.
    Cancer Res. 1985 Jun;45(6):2866-72 PMID: 3921249
  3. Effect of desialylation of human chorionic gonadotropin on its metabolic clearance rate in humans.
    J Clin Endocrinol Metab. 1984 Dec;59(6):1215-9 PMID: 6490798
  4. Interferon kinetics and adverse reactions after intravenous, intramuscular, and subcutaneous injection.
    Clin Pharmacol Ther. 1984 May;35(5):722-7 PMID: 6713784
  5. Quantification of recombinant interleukin-2 in human serum by a specific immunobioassay.
    Anal Chem. 1989 Aug 1;61(15):1732-6 PMID: 2672878
  6. Renal filtration, transport, and metabolism of low-molecular-weight proteins: a review.
    Kidney Int. 1979 Sep;16(3):251-70 PMID: 393891
  7. Metabolic interaction of recombinant interferon-beta and zidovudine in AIDS patients.
    J Interferon Res. 1991 Jun;11(3):159-64 PMID: 1919075
  8. Rapid enzymatic degradation of growth hormone-releasing hormone by plasma in vitro and in vivo to a biologically inactive product cleaved at the NH2 terminus.
    J Clin Invest. 1986 Oct;78(4):906-13 PMID: 3093533
  9. A decade of development in immunoassay methodology.
    Clin Chem. 1990 Aug;36(8 Pt 1):1408-27 PMID: 2201458
  10. Protein blotting and immunodetection.
    Methods Enzymol. 1990;182:679-88 PMID: 2314263
  11. Effects of three recombinant human leukocyte interferons on drug metabolism in mice.
    Drug Metab Dispos. 1982 Nov-Dec;10(6):579-85 PMID: 6130903
  12. Delivering peptides to the central nervous system: dilemmas and strategies.
    Pharm Res. 1991 Nov;8(11):1345-50 PMID: 1798668
  13. The effect of pulsatile administration, continuous infusion, and diurnal variation on the growth hormone (GH) response to GH-releasing hormone in normal men.
    J Clin Endocrinol Metab. 1986 Oct;63(4):872-8 PMID: 3091629
  14. The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11.
    Biochem J. 1984 Oct 15;223(2):433-40 PMID: 6149747
  15. Metabolism of dipeptides and their constituent amino acids by liver, gut, kidney, and muscle.
    Am J Physiol. 1988 May;254(5 Pt 1):E588-94 PMID: 3364562
  16. Renal tubular processing of small peptide hormones.
    J Lab Clin Med. 1982 Jul;100(1):1-14 PMID: 7045258
  17. Treatment of growth-hormone deficiency with growth-hormone-releasing hormone.
    Lancet. 1987 Jan 3;1(8523):5-8 PMID: 2879138
  18. Scaling of renal functions in mammals.
    Comp Biochem Physiol A Comp Physiol. 1975 Sep 1;52(1):63-6 PMID: 240568
  19. Serum IL-2 inhibitor in mice. I. Increase during infection.
    Immunology. 1985 Sep;56(1):113-8 PMID: 3899918
  20. Recombinant tumor necrosis factor depresses cytochrome P450-dependent microsomal drug metabolism in mice.
    Biochem Biophys Res Commun. 1986 Apr 14;136(1):316-21 PMID: 3486657
  21. Influence of the degree of iodination and storage time on the immunological activity of 125 I-IgE.
    Immunochemistry. 1972 May;9(5):565-75 PMID: 5036152
  22. Scaling of respiratory variables in mammals.
    J Appl Physiol. 1967 Mar;22(3):453-60 PMID: 6020227
  23. Role of interleukin-1 in the depression of liver drug metabolism by endotoxin.
    Infect Immun. 1986 Dec;54(3):837-40 PMID: 3491050
  24. Insulin pharmacokinetics following continuous infusion and bolus injection of regular porcine and human insulin in healthy man.
    Metabolism. 1983 May;32(5):478-86 PMID: 6341763
  25. A comparison of mass balance, pharmacokinetics and disposition of [14C(U)]- and [125I]recombinant human interleukin-2 in cynomolgus monkeys.
    Drug Metab Dispos. 1995 Sep;23(9):904-9 PMID: 8565779
  26. Pharmacokinetics of recombinant human interferon-gamma in the rhesus monkey after intravenous, intramuscular, and subcutaneous administration.
    J Biol Response Mod. 1988 Apr;7(2):115-22 PMID: 3129541
  27. Protein degradation: the role of mixed-function oxidases.
    Pharm Res. 1987 Aug;4(4):278-84 PMID: 3334164
  28. Bioassays in modern peptide research.
    Peptides. 1982 May-Jun;3(3):223-30 PMID: 6289275
  29. Administered peptides inhibit the degradation of endogenous peptides. The dilemma of distinguishing direct from indirect effects.
    Peptides. 1985 Jul-Aug;6(4):645-60 PMID: 2999731
  30. The half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin.
    Clin Endocrinol (Oxf). 1989 Apr;30(4):443-50 PMID: 2574646
  31. Immunomodulators as local hormones: new insights regarding their clinical utilization.
    J Biol Response Mod. 1985 Aug;4(4):340-52 PMID: 2411878
  32. Results of 1-year growth hormone (GH)-releasing hormone-(1-44) treatment on growth, somatomedin-C, and 24-hour GH secretion in six children with partial GH deficiency.
    J Clin Endocrinol Metab. 1987 Aug;65(2):268-74 PMID: 3110202
  33. Variations of interferon inactivators and/or inhibitors in human serum and their relationship to interferon therapy.
    Jpn J Med Sci Biol. 1985 Jun;38(3):107-11 PMID: 4068346
  34. Investigation by HPLC of the catabolism of recombinant tissue plasminogen activator in the rat.
    Thromb Haemost. 1988 Aug 30;60(1):107-12 PMID: 3142088
  35. Quantitative Relations in the Physiological Constitutions of Mammals.
    Science. 1949 Jun 10;109(2841):579-85 PMID: 17835379
  36. Survival of recombinant erythropoietin in the circulation: the role of carbohydrates.
    Blood. 1989 Jan;73(1):84-9 PMID: 2910371
  37. Inhibition of antipyrine metabolism by interferon.
    Br J Clin Pharmacol. 1986 Nov;22(5):610-2 PMID: 3790409
  38. Inhibition of theophylline metabolism by interferon.
    Lancet. 1987 Oct 24;2(8565):939-41 PMID: 2444839
  39. Disappearance rates of exogenous and endogenous ACTH from rat plasma measured by bioassay and radioimmunoassay.
    Metabolism. 1972 Jan;21(1):30-5 PMID: 4332578
  40. The effect of circulating growth hormone-binding protein on metabolic clearance, distribution, and degradation of human growth hormone.
    J Clin Endocrinol Metab. 1987 Apr;64(4):657-60 PMID: 3818897
  41. Interferon reduces hepatic drug metabolism in vivo in mice.
    Drug Metab Dispos. 1985 Jul-Aug;13(4):459-63 PMID: 2863111
  42. Effects of alpha-interferon on theophylline pharmacokinetics and metabolism.
    Br J Clin Pharmacol. 1989 Jun;27(6):795-802 PMID: 2757895
  43. Proteins in bile: how they get there and what they do.
    Am J Physiol. 1984 Sep;247(3 Pt 1):G199-205 PMID: 6383073
  44. Receptor-mediated transport of peptide hormones and its importance in the overall hormone disposition in the body.
    Pharm Res. 1989 Mar;6(3):192-202 PMID: 2542919
  45. Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins.
    Pharm Res. 1991 Nov;8(11):1351-9 PMID: 1798669
  46. The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins.
    Adv Enzymol Relat Areas Mol Biol. 1974;41(0):99-128 PMID: 4609051
  47. Immunoprecipitation of proteins.
    Methods Enzymol. 1990;182:688-700 PMID: 2179670
  48. Electrophoresis and densitometry of serum and urine in the investigation and significance of monoclonal immunoglobulins.
    Electrophoresis. 1990 May;11(5):376-81 PMID: 2194791
  49. The pharmacokinetics and metabolism of human relaxins in rhesus monkeys.
    Pharm Res. 1991 Aug;8(8):1032-8 PMID: 1924156
  50. Role of the carbohydrate moiety in determining the survival of interferon in the circulation.
    J Biol Chem. 1977 Dec 10;252(23):8336-7 PMID: 924995
Article Info
Journal
Clinical pharmacokinetics
Abbr.
Clin Pharmacokinet
ISSN
0312-5963
DOI
10.2165/00003088-199223060-00002
Published
1992-12-00
Pages
406-14
Language
English
Region
Switzerland
NLM ID
7606849
Subset
IM
External Links
PubMed source DOI: 10.2165/00003088-199223060-00002 View journal details
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