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PMID: 14577832 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium.

Reproductive biology and endocrinology : RB&E ·Vol. 1 ·2003-10-07 ·Pages 71

Choi KC, Auersperg N, Leung PC

Abstract

Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. It has been demonstrated that MAPKs are activated by external stimuli including chemotherapeutic agents, growth factors and reproductive hormones in ovarian surface epithelial cells. Thus, the MAPK signaling pathway may play an important role in the regulation of proliferation, survival and apoptosis in response to these external stimuli in ovarian cancer. In this article, an activation of the MAPK signaling cascade by several key reproductive hormones and growth factors in epithelial ovarian cancer is reviewed.

MeSH Terms
Antineoplastic Agents/pharmacology Apoptosis/drug effects,physiology Cell Division/drug effects,physiology Cytokines/pharmacology Enzyme Activation/drug effects,genetics Epithelial Cells/enzymology Epithelium/enzymology Female Growth Substances/pharmacology Hormones/pharmacology Humans MAP Kinase Signaling System/drug effects Mitogen-Activated Protein Kinases/physiology Neoplasm Proteins/physiology Ovarian Diseases/enzymology Ovarian Neoplasms/enzymology Precancerous Conditions/enzymology
Chemicals
Antineoplastic Agents Cytokines Growth Substances Hormones Neoplasm Proteins Mitogen-Activated Protein Kinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Choi Kyung-Chul
Department of Obstetrics and Gynaecology, BC Children's and Women's Hospital, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5. kchoi@cw.bc.ca
Auersperg Nelly
Leung Peter C K
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Article Info
Journal
Reproductive biology and endocrinology : RB&E
Abbr.
Reprod Biol Endocrinol
ISSN
1477-7827
DOI
10.1186/1477-7827-1-71
Email
kchoi@cw.bc.ca
Published
2003-10-07
Epub
2003-00-07
Pages
71
Language
English
Region
England
NLM ID
101153627
PMCID
PMC239898
Subset
IM
External Links
PubMed source DOI: 10.1186/1477-7827-1-71 PMC Full Text View journal details
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