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PMID: 14575531 Published · ppublish English Journal Article Review

At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation.

Journal of biology ·Vol. 2 ·No. 4 ·2003-00-00 ·Pages 26

Kyriakis JM

Abstract

The tumor suppressor kinase LKB1 has been identified as a physiologic activator of the key metabolic regulator 5'-AMP-activated protein kinase, establishing a possible molecular link between the regulation of metabolism and cell proliferation.

MeSH Terms
AMP-Activated Protein Kinase Kinases AMP-Activated Protein Kinases Animals Cell Growth Processes/physiology Cell Proliferation Genes, Tumor Suppressor/physiology Humans Multienzyme Complexes/physiology Protein Serine-Threonine Kinases/physiology
Chemicals
Multienzyme Complexes Protein Serine-Threonine Kinases STK11 protein, human AMP-Activated Protein Kinase Kinases AMP-Activated Protein Kinases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kyriakis John M
Molecular Cardiology Research Institute, Tufts-New England Medical Center, 750 Washington Street, Boston, MA 02111, USA. jkyriakis@tufts-nemc.org
References (26)
26 references, click to expand
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Article Info
Journal
Journal of biology
Abbr.
J Biol
ISSN
1475-4924
DOI
10.1186/1475-4924-2-26
Email
jkyriakis@tufts-nemc.org
Published
2003-00-00
Epub
2003-00-22
Pages
26
Language
English
Region
England
NLM ID
101147570
PMCID
PMC333408
Subset
IM
External Links
PubMed source DOI: 10.1186/1475-4924-2-26 PMC Full Text
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