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PMID: 1457351 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours.

British journal of cancer ·Vol. 66 ·No. 6 ·1992-12-00 ·Pages 1099-102

Walenta S, Dellian M, Goetz AE, Kuhnle GE, Mueller-Klieser W

Abstract

Iodo(14C-)antipyrine autoradiography and imaging bioluminescence have been combined to obtain pixel-to-pixel correlations between absolute values for local blood flow and ATP concentrations at a microscopical level within designated areas in hamster melanomas. Positive pixel-to-pixel correlations were obtained in 4 of 6 tumours. Both flow and ATP values were less in mostly necrotic than in mostly viable tumour regions. The data provide evidence for the energetic state of cancer cells being strongly influenced by the efficiency of tumour microcirculation in several but not in all malignancies investigated.

MeSH Terms

Adenosine Triphosphate/analysis Animals Antipyrine/analogs & derivatives Autoradiography Cricetinae Luminescent Measurements Melanoma/blood supply,chemistry,pathology Mesocricetus Necrosis Regional Blood Flow Skin Neoplasms/blood supply,chemistry,pathology

Chemicals

Adenosine Triphosphate Antipyrine iodoantipyrine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Walenta S

Institute of Physiology and Pathophysiology, University of Mainz, Germany.

Dellian M

Goetz A E

Kuhnle G E

Mueller-Klieser W

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15 references, click to expand

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Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1992.417

Published

1992-12-00

Pages

1099-102

Language

English

Region

England

NLM ID

0370635

PMCID

PMC1978060

Subset

External Links

PubMed source DOI: 10.1038/bjc.1992.417 PMC Full Text View journal details

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Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours.

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