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PMID: 14570590 Published · ppublish English Journal Article Review

Emerging and diverse roles of protein kinase C in immune cell signalling.

The Biochemical journal ·Vol. 376 ·No. Pt 3 ·2003-12-15 ·Pages 545-52

Tan SL, Parker PJ

Abstract

Members of the protein kinase C (PKC) family are expressed in many different cell types, where they are known to regulate a wide variety of cellular processes that impact on cell growth and differentiation, cytoskeletal remodelling and gene expression in the response to diverse stimuli. The broad tissue distribution and redundancy of in vitro function have often hampered the identification of definitive roles for each PKC family member. However, recent in vivo studies of PKC isoenzyme-selective knockout and transgenic mice have highlighted distinct functions of individual PKCs in the immune system. These genetic analyses, along with biochemical studies utilizing PKC isoenzyme-specific cDNA (wild-type, constitutively active and dominant-negative), antisense oligonucleotides (ASO), RNA interference (RNAi), and pharmacological inhibitors, indicate that PKC-regulated signalling pathways play a significant role in many aspects of immune responses, from development, differentiation, activation and survival of lymphocytes to macrophage activation. The importance of PKCs in cellular immune responses suggests that improved understanding of the molecular events that govern their actions could point to new avenues for development of treatments for immune disorders.

MeSH Terms
Animals B-Lymphocytes/enzymology,immunology Immune System/cytology,enzymology Immunity, Innate Isoenzymes/physiology Macrophages/enzymology,immunology Mast Cells/enzymology,immunology Mice Protein Kinase C/physiology Signal Transduction T-Lymphocytes/enzymology,immunology Thymus Gland/cytology,growth & development,immunology
Chemicals
Isoenzymes Protein Kinase C
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tan Seng-Lai
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
Parker Peter J
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
1470-8728
DOI
10.1042/BJ20031406
Published
2003-12-15
Pages
545-52
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1223826
Subset
IM
External Links
PubMed source DOI: 10.1042/BJ20031406 PMC Full Text View journal details
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