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PMID: 1456897 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Eosinophils as host cells for HIV-1.

Archives of virology ·Vol. 127 ·No. 1-4 ·1992-00-00 ·Pages 373-7

Conway B, Baskar P, Bechtel LJ, Kaplan JC, Hirsch MS, Schooley RT, Pincus SH

Abstract

Transient expression of HIV-1 p24 antigen was observed in eosinophils acutely infected with the HTLV-IIIB strain of HIV-1. PCR analysis of eosinophils isolated from 18 seropositive individuals showed HIV-1 sequences to be present in 2 subjects. These data suggest that eosinophils may act as host cells for HIV-1.

MeSH Terms

DNA, Viral/analysis Eosinophils/microbiology HIV Antigens/analysis HIV Core Protein p24/metabolism HIV Infections/blood HIV-1/growth & development,immunology Humans Polymerase Chain Reaction Virus Replication

Chemicals

DNA, Viral HIV Antigens HIV Core Protein p24

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Conway B

Infectious Diseases Unit, Massachusetts General Hospital, Boston.

Baskar P

Bechtel L J

Kaplan J C

Hirsch M S

Schooley R T

Pincus S H

References (8)

8 references, click to expand

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Bronchoalveolar lavage eosinophilia associated with Pneumocystis carinii pneumonitis in AIDS patients. Comparative study with non-AIDS patients.
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Human eosinophils express CD4 protein and bind human immunodeficiency virus 1 gp120.
J Exp Med. 1989 Jan 1;169(1):327-32 PMID: 2783333
Transient expression of human immunodeficiency virus type 1 genome results in a nonproductive infection in human fetal dorsal root ganglia glial cells.
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Two-drug combinations of zidovudine, didanosine, and recombinant interferon-alpha A inhibit replication of zidovudine-resistant human immunodeficiency virus type 1 synergistically in vitro.
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Article Info

Journal

Archives of virology

Abbr.

Arch Virol

ISSN

0304-8608

DOI

10.1007/BF01309600

Published

1992-00-00

Pages

373-7

Language

English

Region

Austria

NLM ID

7506870

Subset

Grants

NIAID NIH HHS · AI16432 · United States

NIAID NIH HHS · AI24847 · United States

NCI NIH HHS · CA12464 · United States

External Links

PubMed source DOI: 10.1007/BF01309600 View journal details

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