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PMID: 14563678 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Ceramides modulate programmed cell death in plants.

Genes & development ·Vol. 17 ·No. 21 ·2003-11-01 ·Pages 2636-41

Liang H, Yao N, Song JT, Luo S, Lu H, Greenberg JT

Abstract

The balance between the bioactive sphingolipid ceramide and its phosphorylated derivative has been proposed to modulate the amount of programmed cell death (PCD) in eukaryotes. We characterized the first ceramide kinase (CERK) mutant in any organism. The Arabidopsis CERK mutant, called accelerated cell death 5, accumulates CERK substrates and shows enhanced disease symptoms during pathogen attack and apoptotic-like cell death dependent on defense signaling late in development. ACD5 protein shows high specificity for ceramides in vitro. Strikingly, C2 ceramide induces, whereas its phosphorylated derivative partially blocks, plant PCD, supporting a role for ceramide phosphorylation in modulating cell death in plants.

MeSH Terms
Apoptosis/physiology Arabidopsis/metabolism Ceramides/metabolism
Chemicals
Ceramides
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Liang Hua
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA. jgreenbe@midway.uchicago.edu
Yao Nan
Song Jong Tae
Luo Song
Lu Hua
Greenberg Jean T
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.1140503
Email
jgreenbe@midway.uchicago.edu
Published
2003-11-01
Epub
2003-00-16
Pages
2636-41
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC280613
Subset
IM
External Links
PubMed source DOI: 10.1101/gad.1140503 PMC Full Text View journal details
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