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题目:: A relationship between Matrix metalloproteinase-1 (MMP-1) promoter polymorphism and cervical cancer progression.
作者:: Nishioka(Yoshihiro),Sagae(Satoru),Nishikawa(Akira),Ishioka(Shin ichi),Kudo(Ryuichi)
状态:: 发布时间2003-10-10 , 更新时间 2008-11-21
期刊:: Cancer Lett
摘要:: Single nucleotide polymorphism (SNP) of the promoter region of MMP-1 (at -1607 bp) creates Ets binding sites, and correlations between this SNP and cancer susceptibility have been reported for various cancers. In this study, we genotyped the SNP in 23 cervical intraepithelial neoplasias (CIN) and 86 cervical cancer specimens. We found a correlation between promoter polymorphism and MMP-1 expression, and that this SNP was correlated with the clinical stage of cervical cancer. These findings suggested that SNP of MMP-1 promoter might influence the ability in cervical cancer invasion via transcriptional activity of this gene.
语言:: eng
DOI:

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