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LiteratureArticle Details
PMID: 14530376
Published · ppublish
English
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.
Abstract
Natural killer (NK) and NK T cells are tissue lymphocytes that secrete cytokines rapidly upon stimulation. Here, we show that these cells maintain distinct patterns of constitutive cytokine mRNAs. Unlike conventional T cells, NK T cells activate interleukin (IL)-4 and interferon (IFN)-gamma transcription during thymic development and populate the periphery with both cytokine loci previously modified by histone acetylation. Similarly, NK cells transcribe and modify the IFN-gamma gene, but not IL-4, during developmental maturation in the bone marrow. Lineage-specific patterns of cytokine transcripts predate infection and suggest evolutionary selection for invariant but distinct types of effector responses among the earliest responding lymphocytes.
MeSH Terms
Animals
Chromatin/metabolism
Fluorescence
Interferon-gamma/genetics
Interleukin-4/genetics
Killer Cells, Natural/immunology,physiology
Mice
Mice, Inbred C57BL
Promoter Regions, Genetic
RNA, Messenger/analysis
T-Lymphocytes/immunology,physiology
Transcription, Genetic
Chemicals
Chromatin
RNA, Messenger
Interleukin-4
Interferon-gamma
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
2003-10-06
Pages
1069-76
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2194220
Subset
IM
Grants
NHLBI NIH HHS · P50 HL056385 · United States
NHLBI NIH HHS · HL 56385 · United States
NCI NIH HHS · CA 52511 · United States
NIAID NIH HHS · AI 30663 · United States
NCI NIH HHS · R01 CA052511 · United States
NIAID NIH HHS · R01 AI030663 · United States
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