Novel data point to a broader mechanism of action of oxidized ATP: the P2X7 receptor is not the only target.

British journal of pharmacology ·Vol. 140 ·No. 3 ·2003-10-00 ·Pages 441-3

Di Virgilio F

Abstract

Oxidized ATP (oATP) is a Schiff-base-forming reagent that has been used for some years as an antagonist at the P2X7 receptor (P2X7R). Preincubation of mononuclear phagocytes with this inhibitor leads to attenuation of several proinflammatory responses triggered by extracellular ATP as well as a few non-nucleotide agonists. Novel data show that oATP reduces NFkappaB activation and IL-8 release in cells lacking P2X7R, thus suggesting that some anti-inflammatory effects of oATP may not be due to blockade of the P2X7R. This effect of oATP resembles the action of other natural or synthetic Schiff-base-forming reagents with immunomodulatory activity.

MeSH Terms

Adenosine Triphosphate/metabolism,pharmacology Animals Humans Oxidation-Reduction Purinergic P2 Receptor Antagonists Receptors, Purinergic P2/metabolism Receptors, Purinergic P2X7

Chemicals

P2RX7 protein, human Purinergic P2 Receptor Antagonists Receptors, Purinergic P2 Receptors, Purinergic P2X7 Adenosine Triphosphate

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Di Virgilio Francesco

Department of Experimental and Diagnostic Medicine, University of Ferrara, Via Borsari 46, I-44100 Ferrara, Italy. fdv@unife.it

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14 references, click to expand

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Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1038/sj.bjp.0705469

fdv@unife.it

Published

2003-10-00

Pages

441-3

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1574057

Subset

Corrections

CommentOn

PMID: 14522842

External Links

PubMed source DOI: 10.1038/sj.bjp.0705469 PMC Full Text View journal details

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Novel data point to a broader mechanism of action of oxidized ATP: the P2X7 receptor is not the only target.

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