Home LiteratureArticle Details
PMID: 14512627 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

The dog genome: survey sequencing and comparative analysis.

Science (New York, N.Y.) ·Vol. 301 ·No. 5641 ·2003-09-26 ·Pages 1898-903

Kirkness EF, Bafna V, Halpern AL, Levy S, Remington K, Rusch DB, Delcher AL, Pop M, Wang W, Fraser CM, Venter JC

Abstract

A survey of the dog genome sequence (6.22 million sequence reads; 1.5x coverage) demonstrates the power of sample sequencing for comparative analysis of mammalian genomes and the generation of species-specific resources. More than 650 million base pairs (>25%) of dog sequence align uniquely to the human genome, including fragments of putative orthologs for 18,473 of 24,567 annotated human genes. Mutation rates, conserved synteny, repeat content, and phylogeny can be compared among human, mouse, and dog. A variety of polymorphic elements are identified that will be valuable for mapping the genetic basis of diseases and traits in the dog.

MeSH Terms
Animals Chromosomes, Mammalian/genetics Computational Biology Conserved Sequence Contig Mapping DNA, Intergenic Dogs/genetics Genetic Variation Genome Genome, Human Genomics Humans Long Interspersed Nucleotide Elements Male Mice/genetics Molecular Sequence Data Mutation Phylogeny Physical Chromosome Mapping Polymorphism, Single Nucleotide RNA, Messenger/genetics Repetitive Sequences, Nucleic Acid Sequence Alignment Sequence Analysis, DNA Short Interspersed Nucleotide Elements Synteny
Chemicals
DNA, Intergenic RNA, Messenger
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Kirkness Ewen F
The Institute for Genomic Research, Rockville, MD 20850, USA.
Bafna Vineet
Halpern Aaron L
Levy Samuel
Remington Karin
Rusch Douglas B
Delcher Arthur L
Pop Mihai
Wang Wei
Fraser Claire M
Venter J Craig
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2003-09-26
Pages
1898-903
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Databases
GENBANK
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