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PMID: 14502292 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Regulation of acetylcholine receptor clustering by the tumor suppressor APC.

Nature neuroscience ·Vol. 6 ·No. 10 ·2003-10-00 ·Pages 1017-8

Wang J, Jing Z, Zhang L, Zhou G, Braun J, Yao Y, Wang ZZ

Abstract

At the developing neuromuscular junction, motor neuron-derived agrin triggers the differentiation of postsynaptic membrane into a highly specialized structure, where the nicotinic acetylcholine receptors (AChRs) are aggregated into high-density clusters. Agrin acts by activating the muscle-specific kinase MuSK and inducing coaggregation of the 43-kDa protein rapsyn with AChRs on muscle cell membrane. The signaling mechanism downstream of MuSK is poorly defined. We report here that the mouse tumor suppressor protein adenomatous polyposis coli (APC) has a role in AChR clustering and that the Wnt/beta-catenin pathway may crosstalk with agrin signaling cascade during synapse formation.

MeSH Terms

Adenomatous Polyposis Coli Protein/metabolism Agrin/metabolism,pharmacology Animals Cell Differentiation/drug effects,physiology Cells, Cultured Cytoskeletal Proteins/metabolism Gene Expression Regulation/drug effects,genetics Mice Muscle Denervation Muscle Fibers, Skeletal/drug effects,metabolism Muscle, Skeletal/embryology,innervation,metabolism Neuromuscular Junction/cytology,embryology,metabolism Protein Structure, Tertiary/drug effects,physiology Proto-Oncogene Proteins/metabolism Receptor Aggregation/drug effects,physiology Receptor Protein-Tyrosine Kinases/metabolism Receptors, Cholinergic/metabolism Receptors, Nicotinic/drug effects,genetics,metabolism Recombinant Fusion Proteins/pharmacology Signal Transduction/drug effects,physiology Trans-Activators/metabolism Wnt Proteins Zebrafish Proteins beta Catenin

Chemicals

Adenomatous Polyposis Coli Protein Agrin CTNNB1 protein, mouse Cytoskeletal Proteins Proto-Oncogene Proteins Receptors, Cholinergic Receptors, Nicotinic Recombinant Fusion Proteins Trans-Activators Wnt Proteins Zebrafish Proteins beta Catenin MuSK protein, rat Receptor Protein-Tyrosine Kinases

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Wang Junmei

Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Room E1440 BST, Pittsburgh, Pennsylvania 15261, USA.

Jing Zheng

Zhang Lili

Zhou Guangdou

Braun Joe

Yao Yun

Wang Zuo-Zhong

Article Info

Journal

Nature neuroscience

Abbr.

Nat Neurosci

ISSN

1097-6256

DOI

10.1038/nn1128

Published

2003-10-00

Epub

2003-00-21

Pages

1017-8

Language

English

Region

United States

NLM ID

9809671

Subset

External Links

PubMed source DOI: 10.1038/nn1128 View journal details

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