Stimulation of intestinal nervous elements by angiotensin.

British journal of pharmacology and chemotherapy ·Vol. 19 ·1962-08-00 ·Pages 5-12

ROBERTSON PA, RUBIN D

Abstract

The stimulation of nervous elements in the intestine by the polypeptide angiotensin has been examined. Comparisons between nicotine, a neurotropic agent, acetylcholine which exerts principally a musculotropic action and angiotensin have been made by examining their interactions with hexamethonium and the anticholinesterase 1,5-di-(p-N-allyl-N-methylaminophenyl)pentan-3-one dibromide in both the rabbit and guinea-pig ileum. The effect of atropine on the responses of the guinea-pig ileum and botulinum toxin on the responses of the rabbit ileum to angiotensin was also tested. The results show that angiotensin causes most of its contractile response in both the guinea-pig and rabbit ileum by an indirect action, through the stimulation of nervous tissue.

Keywords

HYPERTENSIN/pharmacology INTESTINES/pharmacology

MeSH Terms

Acetylcholine Angiotensin Amide/pharmacology Angiotensins Animals Atropine Guinea Pigs Hexamethonium Ileum Intestines/pharmacology Muscle Contraction Nicotine Rabbits

Chemicals

Angiotensins Hexamethonium Angiotensin Amide Nicotine Atropine Acetylcholine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

ROBERTSON P A

RUBIN D

References (15)

15 references, click to expand

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Article Info

Journal

British journal of pharmacology and chemotherapy

Abbr.

Br J Pharmacol Chemother

ISSN

0366-0826

DOI

10.1111/j.1476-5381.1962.tb01423.x

Published

1962-08-00

Pages

5-12

Language

English

Region

England

NLM ID

0154627

PMCID

PMC1482242

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1962.tb01423.x PMC Full Text

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Stimulation of intestinal nervous elements by angiotensin.

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