A second gene for a secreted aspartate proteinase in Candida albicans.
The gene (PRA11) encoding a secreted aspartate proteinase of Candida albicans has been cloned and sequenced. The nucleotide and deduced amino acid sequences of PRA11 are 77 and 73% identical, respectively, with the reported sequences of PRA10 also cloned from C. albicans. Southern analyses indicated that the genome of each strain examined (ATCC 10231 and ATCC 10261) contains PRA10 and PRA11. Northern (RNA) analyses showed that PRA11 was expressed at a much higher level than was PRA10 when secretion of the proteinase by strain ATCC 10261 was induced with albumin.
21 references, click to expand
-
DNA sequencing with chain-terminating inhibitors.Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
-
A comparison of secretory proteinases from different strains of Candida albicans.Sabouraudia. 1982 Sep;20(3):233-44 PMID: 6753190
-
Sequence of the Candida albicans gene encoding the secretory aspartate proteinase.J Med Vet Mycol. 1991;29(2):129-32 PMID: 1880680
-
A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae.Nucleic Acids Res. 1990 May 25;18(10):3091-2 PMID: 2190191
-
Fast and sensitive multiple sequence alignments on a microcomputer.Comput Appl Biosci. 1989 Apr;5(2):151-3 PMID: 2720464
-
Proteases and the processing of precursors to secreted proteins in yeast.Yeast. 1988 Mar;4(1):17-26 PMID: 3059710
-
A new method for predicting signal sequence cleavage sites.Nucleic Acids Res. 1986 Jun 11;14(11):4683-90 PMID: 3714490
-
Serum-proteins as nitrogen source for yeastlike fungi.Sabouraudia. 1965 Oct;4(3):187-93 PMID: 5873694
-
Properties of a purified proteinase from the yeast Candida albicans.Biochim Biophys Acta. 1981 May 14;659(1):99-113 PMID: 7018586
-
Isolation of yeast DNA.Methods Cell Biol. 1975;12:39-44 PMID: 1105072
-
Transcription of the gene for a pepsinogen, PEP1, is regulated by white-opaque switching in Candida albicans.Mol Cell Biol. 1992 Jul;12(7):2997-3005 PMID: 1620110
-
Comparative production and rapid purification of Candida acid proteinase from protein-supplemented cultures.Infect Immun. 1990 Feb;58(2):508-14 PMID: 1688827
-
Molecular cloning of the secretory acid proteinase gene from Candida albicans and its use as a species-specific probe.Infect Immun. 1991 Sep;59(9):2972-7 PMID: 1879921
-
Evidence for a role for secreted aspartate proteinase of Candida albicans in vulvovaginal candidiasis.J Infect Dis. 1990 Jun;161(6):1276-83 PMID: 2189009
-
The secreted aspartate proteinase of Candida albicans: physiology of secretion and virulence of a proteinase-deficient mutant.J Gen Microbiol. 1990 Apr;136(4):687-94 PMID: 2204678
-
Nucleotide sequence of the Candida albicans aspartyl proteinase gene.Nucleic Acids Res. 1989 Feb 25;17(4):1779 PMID: 2646602
-
PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors.Mol Cell Biol. 1986 Jul;6(7):2490-9 PMID: 3023936
-
Evidence for a correlation between proteinase secretion and vulvovaginal candidosis.J Infect Dis. 1987 Nov;156(5):777-83 PMID: 3309073
-
Molecular mechanisms of protein secretion: the role of the signal sequence.Adv Protein Chem. 1986;38:109-80 PMID: 3541538
-
VTUTIN: a full screen gel management editor.Comput Appl Biosci. 1985 Dec;1(4):253-9 PMID: 3880348
-
Isolation and nucleotide sequence of the extracellular acid protease gene (ACP) from the yeast Candida tropicalis.FEBS Lett. 1991 Jul 29;286(1-2):181-5 PMID: 1864366
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
