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题目:: T cells which proliferate in response to concanavalin A include cells which proliferate in mixed leucocyte reactions.
作者:: Watanabe(T),Fathman(C G),Coutinho(A)
状态:: 发布时间1978-01-27 , 更新时间 2014-11-20
期刊:: Eur J Immunol
摘要:: Selection in long-term culture of alloreactive T cells, by successive in vitro restimulation with semi-allogeneic cells, results in primed responder cell populations which maintain full proliferative reactivity to allogeneic cells as well as to the T cell mitogens concanavalin A (Con A) and phytohemagglutinin (PHA) but are depleted of cells which can effect target cell destruction in either a specific or nonspecific manner. Con A-induced T cell blasts (selected by velocity sedimentation) can revert to small resting lymphocytes in the presence of inert "filler" cells. Con A blasts which have reverted, readily proliferate in response to Con A or allogeneic stimulator cells but are largely depleted of effector killer cells and PHA-responsive cells.
语言:: eng
DOI:: 10.1002/eji.1830070905

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